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Hi, My Name is DeltaFosB: A Sustained Molecuar switch for addiction

worstcase · 2009-01-31 08:05:50

For those contemplating giving up alcohol and/or other addictive substances, you may want to read the following article. "The longevity of some of the behavioral abnormalities that characterize drug addiction has suggested that regulation of neural gene expression may be involved in the process by which drugs of abuse…

31-01-2009 9:05am

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worstcase

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For those contemplating giving up alcohol and/or other addictive substances, you may want to read the following article.

"The longevity of some of the behavioral abnormalities that characterize drug addiction has suggested that regulation of neural gene expression may be involved in the process by which drugs of abuse cause a state of addiction. Increasing evidence suggests that the transcription factor ΔFosB represents one mechanism by which drugs of abuse produce relatively stable changes in the brain that contribute to the addiction phenotype. ΔFosB, a member of the Fos family of transcription factors, accumulates within a subset of neurons of the nucleus accumbens and dorsal striatum (brain regions important for addiction) after repeated administration of many kinds of drugs of abuse."'

Source: http://www.pnas.org/content/98/20/11042.full

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