Liveline Thread (15/02/2012 to 01/05/2012)

surferdudz

my friend wrote: »

I am waiting for the revelation about the trip to the miraculous Gerry Ryan Bench

and dont forget Padre Pio's glove...

telekon

I'm giving this til 2pm and then the radio's going off....

surferdudz

did she get married in the end??

JonathanAnon

telekon wrote: »

Have you hacked my computer?

Dont be complaining, I left your stash of "adult art movies" alone.. (though I did take a copy)..

telekon

The show was actually better last week with Damo in the chair. That's how bad it is.

JonathanAnon

"The Government have decided that it's too expensive"...

No Joe, the Government have decided that you, Tubridy and thousands of other public servants are NOT too expensive..

telekon

JonathanAnon wrote: »

Dont be complaining, I left your stash of "adult art movies" alone.. (though I did take a copy)..

Erm, they were already there when I got it...

my friend

harsh truths on Ippy

A total of 676 melanoma patients were enrolled. Drugs were given to patients in a ratio of approximately 3:1:1. That is, about three times as many were given ipilimumab plus gp100 as either ippy alone or gp100 alone:
Number of Enrolled Subjects Ippy
Plus Gp100 Ippy
Alone Gp100
Alone 403 137 136 By the end of 55 months, all the patients had died. Neither ippy nor gp100 saved any lives. At the end of two years, the results didn't look much better. At 12 months, 63% of all the patients had died. At the end of two years, 86% of the patients were dead.


Nearly all the patients had adverse events during the study: 98.4% of the ippy + gp100, 96.9% of the ippy alone, and 97% of the gp100 alone. No discussion of how these events affected quality of life was included in the study, though they included vomiting, abdominal pain, decreased appetite, fatigue, headache, cough, difficulty breathing, anemia, pruritis, rash, vitiligo, diarrhea, colitis, and other disorders that obviously diminish comfort and pleasure in life.
Here are the number of patients from each group who were still alive at 4, 8, 12, and 24 months:
Number (Percent) of Patients Alive Number
of Months Ippy
Plus Gp100 Ippy
Alone Gp100
Alone 4 297 (73.70%) 106 (77.37%) 93 (68.38%) 8 223 (55.33%) 79 (57.66%) 58 (42.65%) 12 163 (40.45%) 56 (41.18%) 32 (23.35%) 24 54 (13.40%) 24 (17.65%) 16 (11.68%) A serious anomaly shows up in this table. Notice that the combination of ippy and gp100 seems to indicate a poorer result than ippy alone? One must wonder if, perhaps, gp100 causes more deaths than placebo. These results might indicate that to be the case. If so, then this entire trial is nothing but a hoax.
The authors claim that the median length of survival was 10.1 months in patients who received ippy alone, 10.0 months in those who received ippy + gp100, and 6.4 months in patients receiving gp100 alone. That sounds impressive—if you don't look at the study as a whole.
There are several glaring flaws in this trial, and the most obvious is the lack of a placebo. It's quite interesting that modern medical pseudoscience insists that a placebo be included in any non-pharmaceutical trial, but seems to have no problem when one isn't used in a trial of a Big Pharma product. In this case, the situation is even worse, since ippy is being compared with an unapproved drug, one that has no track record.
On looking at the actual results in terms of percentages of patients alive over the first two years, the results become downright suspicious. By combining the drug being tested with the control (gp100), a serious anomally becomes apparent:
When ippy is combined with gp100, the number of dead patients increases over ippy alone.
That would indicate that the trial compared ippy against a drug that decreases lifespan.
And that would explain why ippy wasn't trialed against a placebo.
A placebo would do better than a drug that kills more patients than it helps—and it looks like gp100 may do just that, at least in this sort of patient. So, the only benefit this trial seems to show is that ippy helps counteract the ill effects of another drug.
It's [slightly] possible that the action of ippy is depressed when in combination with gp100. But it flies in the face of logic to believe the researchers chose to compare ippy with gp100—instead of the so-called "gold standard" of a placebo—without having some idea of what the results would be.

syklops

telekon wrote: »

Erm, they were already there when I got it...

Ah yes the old "The porn was just resting on my computer/I was looking after it for a friend" story.

telekon

syklops wrote: »

Ah yes the old "The porn was just resting on my computer/I was looking after it for a friend" story.

Yes, my wife is actually THAT stupid.

surferdudz

anyone still there?/

my friend

surferdudz wrote: »

anyone still there?/

his number 1 fan is.....

telekon

2.01pm. I'm outta here. My new strategy from now on is to give it 15 minutes as you can generally tell the way Joe will take the show. And I'm in no form for more misery porn today. Try and enjoy.

RadioRetro

Me gone too, can't stomach this crap.

my friend

Next up, John from Coolock...

John: 'hello Joe'

Joe: 'John, what's wrong John?'

John: 'I want to smoke 60 a day but on the scratch I can only afford 40'

furiousox

Big sign on Joe's desk....

DO NOT UNDER ANY CIRCUMSTANCES SAY
"HOW DOES IT MAKE YOU FEEL...?"

my friend

Pavlova is not recommended for a clapped out Liver

surferdudz

fair dues , yer wan sounds really up beat and motivated...

sudzs

Just tuned in.... what's it all about today??

Rosiestar

the 'Dublin' show......

my friend

Joe: 'go ahead Benny'

Benny' : 'joe, I called Pfizer in Cork, I said, here lads yee are makin the Viagra here in me backyard could ye throw me a couple of shovel loads?'

europa11

Just in.......more misery porn......I'm out! his nipple clamps must be burning.

And another Unfunny Friday to come, hope Lyons Tea are happy to be sponsoring this shlte.



Just hope Moncrieff is in good humour.

JonathanAnon

"Anything we can do"..

Well Joe, you could take a reasonable wage from the state, and stop milking the place dry.. how about that, ye greedy boll1x...

my friend

Its NOT a cure

duFFy is an idiot

do some research you dick

*Ippy was not trialled V a placebo, just other 'failed' treatments, it was always going to shine.... its at best a 'short time buyer'

syklops

2 pages of comments in 40 minutes.

says it all really.

my friend

and Fianna Fail still polling over 20%

you all get what you deserve

my friend

joe is an idiot for not correcting these women

the drug approval is not decided on an individual basis

to allow them to refer to a family member of a TD is ridiculous

thats not how its calculated

Monty Burnz

my friend wrote: »

joe is an idiot for not correcting these women

the drug approval is not decided on an individual basis

to allow them to refer to a family member of a TD is ridiculous

thats not how its calculated

The gombeen/clientelist politics that sunk the country. :mad:

sudzs

I wonder if the Padre Pio brigade are ringing in frantically with the offer of his magic gloves?!

Monty Burnz

sudzs wrote: »

I wonder if the Padre Pio brigade are ringing in frantically with the offer of his magic gloves?!

Did he have a magic hat at all I wonder?