COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

hmmm

https://www.cnbc.com/2020/05/27/scott-gottlieb-widespread-coronavirus-vaccinations-in-2020-unlikely.html

"Dr. Scott Gottlieb told CNBC on Wednesday that it is unlikely there will be widespread deployment of a coronavirus vaccine this year.
“I think we’ll have to have one more cycle of this virus in the fall, heading into the winter, before we get to a vaccine,” the former FDA chief said on “Squawk Box.”
“I really think a vaccine is probably a 2021 event, in terms of having wide availability of a vaccine for the general population,” Gottlieb added."

“It’s reasonable to have confidence that we’re going to get a vaccine for this in the foreseeable future,” Gottlieb said, noting some of the positive signs from early trials and that “all the major pharmaceutical companies that can develop vaccines are now in this race.”

hmmm

2,000 Brazilians to be enrolled in the Oxford trial (they could do with adding a zero to that)
https://g1.globo.com/bemestar/coronavirus/noticia/2020/06/03/2-mil-voluntarios-brasileiros-participam-de-testes-de-vacina-contra-o-covid-19-de-oxford.ghtml

Fauci says a vaccine may not give long-last immunity (the new flu shot?)
https://www.cnbc.com/2020/06/02/dr-anthony-fauci-says-theres-a-chance-coronavirus-vaccine-may-not-provide-immunity-for-very-long.html

ShineOn7

hmmm wrote: »

Fauci says a vaccine may not give long-last immunity (the new flu shot?)
https://www.cnbc.com/2020/06/02/dr-anthony-fauci-says-theres-a-chance-coronavirus-vaccine-may-not-provide-immunity-for-very-long.html

This craic just goes round in more circles every day

is_that_so

Mike3287 wrote: »

They don't have a clue at this stage

Ibuprofen was supposed to make it worse in March and now in June it makes it better

The article mentions two things, a French minister who made a claim and a study to verify that it's OK. It's what scientists do but the internet always knows better!

hmmm

ShineOn7 wrote: »

This craic just goes round in more circles every day

https://www.youtube.com/watch?v=-F_effjerdU

ShineOn7

hmmm wrote: »

https://www.youtube.com/watch?v=F_effjerdU

Vid not working

hmmm

ShineOn7 wrote: »

Vid not working

Fixed now thanks.

ILoveYourVibes

The rush for the vaccine is like this generations man on the moon.

LiquidZeb

ILoveYourVibes wrote: »

The rush for the vaccine is like this generations man on the moon.

There'll be 10 times the prestige if and when there is one. It'll go down as one of sciences great achievements for both fulfilling the need and the timeframe within it'll have been developed.

nocoverart

I can't imagine how scary second wave Spanish Flu was, especially with a World fookin war! almost as scary as Covid 19 with an internet connection.

silverharp

I cant say I like the arrogance of the we know best brigade ,its not like the so called experts have been batting a 100

https://twitter.com/FatEmperor/status/1268324065187704833

hmmm

EU to use 2.7 billion fund to pre-purchase vaccines

https://www.reuters.com/article/us-health-coronavirus-germany-vaccine/eu-to-use-27-billion-fund-to-buy-promising-covid-19-vaccines-idUSKBN23B0SI

"An EU official said it was necessary to do as the United States was doing, even if this meant losing money as many of the vaccines under development are unlikely to be eventually successful.

The bloc is ready to take higher financial risks as it fears not otherwise having rapid access to a vaccine against the virus that has killed 385,000 people worldwide."

is_that_so

A somewhat limited study but drawing some interesting conclusions on when people test positive.

People with COVID-19 are unlikely to spread the new coronavirus if more than eight days have passed since their symptoms began, according to experiments in monkey cells.

http://doi.org/dw8z

Hmmzis

Not a bad result for Tocilizumab. If left to the clinicians to decide when and how much to use it, it seems to be rather usefull.

https://www.medrxiv.org/content/10.1101/2020.06.05.20113738v1

This would be for severe conditions heading for a cytokine storm.

hmmm

https://www.statnews.com/2020/06/04/astrazeneca-lays-out-plan-for-producing-2-billion-doses-of-covid-19-vaccine-if-it-works/

"The drug giant AstraZeneca said Thursday that it has found partners to manufacture and distribute 2 billion doses of the experimental Covid-19 vaccine created by Oxford University, inking a series of deals with non-government organizations and another manufacturer."

I'm just speculating, but they must be seeing something in the current trial data to give them confidence to start manufacturing in such a large scale.

hmmm

Chinese inactivated vaccine showing good results in animal studies
https://www.cell.com/cell/fulltext/S0092-8674(20)30695-4

"Two-dose immunizations using 2 μg/dose of BBIBP-CorV provided highly efficient protection against SARS-CoV-2 intratracheal challenge in rhesus macaques, without detectable antibody-dependent enhancement of infection. In addition, BBIBP-CorV exhibits efficient productivity and good genetic stability for vaccine manufacture. "

Hmmzis

hmmm wrote: »

Chinese inactivated vaccine showing good results in animal studies
https://www.cell.com/cell/fulltext/S0092-8674(20)30695-4

"Two-dose immunizations using 2 μg/dose of BBIBP-CorV provided highly efficient protection against SARS-CoV-2 intratracheal challenge in rhesus macaques, without detectable antibody-dependent enhancement of infection. In addition, BBIBP-CorV exhibits efficient productivity and good genetic stability for vaccine manufacture. "

Holy antibody titres, those are HIGH for this one! Even the 2ųg dose produced 5x higher titres than ChAdOx. The high dose is 10x that. Full serocoversion after 7 days, that's 2x faster than anything else in trials at this point. If this proves out tolerable in humans, it's a very good oldscool vaccine that's easy to mass produce.

Gael23

This inhaler in the UK looks promising

stephenjmcd

Gael23 wrote: »

This inhaler in the UK looks promising

I've read about that, is it the same vaccine that they've been working on for the last while and is already in advanced trials?

Thought it was a normal injection myself so slightly confused how its now an inhaler

Hmmzis

stephenjmcd wrote: »

I've read about that, is it the same vaccine that they've been working on for the last while and is already in advanced trials?

Thought it was a normal injection myself so slightly confused how its now an inhaler

Since there was no link provided, did a goodle-round. It's ChAdOx, the Oxford vaccine candidate. Had no idea they are going the inhaler route. That should hopefully help with the mucosal antibody response (IgA).

stephenjmcd

Hmmzis wrote: »

Since there was no link provided, did a goodle-round. It's ChAdOx, the Oxford vaccine candidate. Had no idea they are going the inhaler route. That should hopefully help with the mucosal antibody response (IgA).

Yeah its the Oxford vaccine alright but never knew they were looking at inhaler, thought it was an injection

hmmm

Can these inhalers be re-used? I know there is concern in the US about a lack of syringes.

Gael23

Some researchers are saying that infection rates are now so low there may not be enough infected people to run clinical trials.

hmmm

Gael23 wrote: »

Some researchers are saying that infection rates are now so low there may not be enough infected people to run clinical trials.

Unfortunately/fortunately there's still lots of infection in South America and the US isn't so great either.

Particularly for medical staff in South America, I imagine many would be quite happy to take part in a phase 3 trial. It was the strategy used to suppress Ebola in West Africa and protect first-responders.

hmmm

Moderna phase 3 to start in the US in July. 30,000 participants. 500 million doses, perhaps 1 billion in 2021 if successful.

hmmm

Johnson & Johnson accelerated the start of their human trials, starting in July. Selected final candidate vaccine. Phase 3 mid-September, with at least 30,000 people and possibly a lot more.

https://www.youtube.com/watch?v=dY1XMcPG9QA

hmmm

Regeneron entering human trials with their antibody drug. They have already treated their first patient. Is not happy with Eli Lilly's approach of a single antibody rather than a cocktail.

https://www.youtube.com/watch?v=D3asj-WgcqY

ShineOn7

Realistically, when do you think we will have a vaccine?

Maybe Q4 of this year for the vulnerable and healthcare workers

And Q1/Q2 of next year for everyone else?

Hmmzis

ShineOn7 wrote: »

Realistically, when do you think we will have a vaccine?

Maybe Q4 of this year for the vulnerable and healthcare workers

And Q1/Q2 of next year for everyone else?

HC workers and outbreak zones should have them starting September if all goes to plan. Once that's in place, the rest of us can actually wait a while. Of course, the sooner we get something safe and effective the better.

In my thinking it's really necessary to protect the healthcare workers and other frontline staff. Then it's basically down to 'ring-fencing' outbreak zones, treat the infected ones and vaccinate everyone in the general area.

After that it's basically down to travel options. If you're going to a place with active infections or going through a big transport hub, get the jab.

sunbabe08

Would that include the likes of folks who are diabetic and that have cancer