What if there is no cure?

ILoveYourVibes

If there is no cure we will just live with it until there is herd immunity in a few generations.

ShineOn7

ILoveYourVibes wrote: »

If there is no cure we will just live with it until there is herd immunity in a few generations.

A few ... generations?

I thought we'd get it when 60% of the population gets it

dennispenn

If no cure is found then it might disappear just like sars did, of which no cure was found and btw, sars originated in china also.

ek motor

ShineOn7 wrote: »

A few ... generations?

I thought we'd get it when 60% of the population gets it

Immunity for other coronaviruses lasts for between a few months and a couple of years. Unlikely we will ever develop herd immunity to SARS-CoV-2.

ShineOn7

ek motor wrote: »

Immunity for other coronaviruses lasts for between a few months and a couple of years. Unlikely we will ever develop herd immunity to SARS-CoV-2.

Aren't we absolutely fúcked without herd immunity?

patnor1011

bennyineire wrote: »

Why do people keep saying it mutates fast when in fact it is slow, drives me around the bend. Where are your facts ?

Here's a little link for you

https://www.livescience.com/coronavirus-mutation-rate.html

Cool. I see you absorb news with speed and ease. Then you should also wonder about its ability to jump from animals to people and then infect whole world in less than 3 months with over 30 different strains already.
This virus in quite new and what you perceive as a "fact" may not be so in a few days. There are scientists who think it is fast and others who think it is slow it is all a matter of perspective.
Truth is there are different strains and if we look at flu vaccination for example that show us that you can get sick even with a vaccine taken so people should not expect that some miracle vaccine is going to put it all away.

patnor1011

SeaBreezes wrote: »

All that lovely vit D from the sun didn't help the Italians or Spanish?

Oh but it did. And still it is. You need to realize that this virus while attacking everyone is having different effect on people. There are people who do have it and do not experience any inconvenience as their body fight it off with ease.
Assymptomatic carriers arent some mythical breed of people - their immune system just works fine so in most of the cases they do not even know they have it. Some other people have a bit of temperature or headache for a day or few and that is it.
Then there are other people mostly old with 2 or more other underlying health issues and they are the ones who are struggling with it.
Even common cold can put someone in ICU while others will walk it off while still working.

Sir Guy who smiles

patnor1011 wrote: »

Then you should also wonder about its ability to jump from animals to people and then infect whole world in less than 3 months with over 30 different strains already.
This virus in quite new and what you perceive as a "fact" may not be so in a few days. There are scientists who think it is fast and others who think it is slow it is all a matter of perspective.

What scientists think it mutates fast?

4068ac1elhodqr

No evidence yet recovered Covid patients cannot be reinfected - WHO
https://www.rte.ie/news/coronavirus/2020/0425/1134740-virus-toll-nears-200-000-as-un-calls-for-global-vaccine/

In a statement, the United Nations heath agency warned against issuing "immunity passports" or "risk-free certificates" to people who have been infected, saying the practice may actually increase the risk of spread as they may ignore standard advice.

Too early it seems to waste billions on mass rollout of testing (if meant to issue immunity digital certificates), until evidence of immunity actually exists in any meaningful way.
Wave2 is forecast for November, might want to wait until that passes.

MadYaker

Not sure how this is even a discussion since multiple ant viral drugs are already being trialed. We'll have effective treatment soon.

ShineOn7

MadYaker wrote: »

Not sure how this is even a discussion since multiple ant viral drugs are already being trialed. We'll have effective treatment soon.

Have you read the thread?

• SARS 1 from 2013 still hasn't got an effective vaccine

• Covid 19 has already mutated into other strains. What if an anti viral drug starts being effective and then the bastárd mutates into a strain that needs another year of research to beat?

• How long before any of these trials get out of the lab? I've read more than once that 90% of all lab tests never get past the lab

ek motor

ShineOn7 wrote: »

Aren't we absolutely fúcked without herd immunity?

No, there's the possibility of an effective vaccine or anti-viral drugs being developed.

ShineOn7

ek motor wrote: »

No, there's the possibility of an effective vaccine or anti-viral drugs being developed.

And, in keeping with the thread's title, what if there's none?

ek motor

ShineOn7 wrote: »

And, in keeping with the thread's title, what if there's none?

I'd imagine a dramatically reduced life expectancy, permanent social distancing of some sort, PPE becoming compulsory. The end of life as we knew it. Possibly an extinction level event, if reinfection proves possible and deadlier due to already damaged organs.

I hope there's a vaccine or effective treatment for this soon.

snoopboggybog

ek motor wrote: »

I'd imagine a dramatically reduced life expectancy, permanent social distancing of some sort, PPE becoming compulsory. The end of life as we knew it. Possibly an extinction level event, if reinfection proves possible and deadlier due to already damaged organs.

I hope there's a vaccine or effective treatment for this soon.

An extinction level? Ah here. When the numbers completely drop Worst case scenario is older people and people with underlying conditions will need to be ultra careful in their day to day lives. That's the worse case scenario.

The restrictions are going to be gradually lifted next month.

patnor1011

ek motor wrote: »

I'd imagine a dramatically reduced life expectancy, permanent social distancing of some sort, PPE becoming compulsory. The end of life as we knew it. Possibly an extinction level event, if reinfection proves possible and deadlier due to already damaged organs.

I hope there's a vaccine or effective treatment for this soon.

I'd imagine a dramatically changed lifestyle, proper nutrition. Less chemicals and preservatives in our food, water, air... That way we beat this virus and many other ailments.

p.s. And no, I will not vote for greens as what they propose is nothing short of global economic suicide.

ek motor

patnor1011 wrote: »

I'd imagine a dramatically changed lifestyle, proper nutrition. Less chemicals and preservatives in our food, water, air... That way we beat this virus and many other ailments.

p.s. And no, I will not vote for greens as what they propose is nothing short of global economic suicide.

How does any of that 'beat' this virus ? This virus is already absolutely flooring even relatively young and healthy people. The only way this virus will be 'beaten' is with a vaccine or totally effective anti viral drugs.

MadYaker

ShineOn7 wrote: »

Have you read the thread?

• SARS 1 from 2013 still hasn't got an effective vaccine

• Covid 19 has already mutated into other strains. What if an anti viral drug starts being effective and then the bastárd mutates into a strain that needs another year of research to beat?

• How long before any of these trials get out of the lab? I've read more than once that 90% of all lab tests never get past the lab

The mutations seen so far aren’t enough to stop a vaccine from being effective. Just because you read random information somewhere doesn’t make it true. We’ll have drugs in a few months and a vaccine next year. If only one of the many drugs being trialled is effective that’s enough, but there’ll be multiple. The flu mutates every year (segmented genome) and we just come up with a new vaccine every year. Coronaviruses are different so that likely won’t be necessary. Vaccine should be effective for many years. But even if we have to make a new vaccine every year that is what will happen.

MadYaker

You’re right about SARS 1 having no vaccine though and yet it has been essentially eliminated or at least massively suppressed. HIV also has no vaccine but most HIV sufferers can live relatively full lives now due the quality of treatments available. There are other solutions even without a vaccine but a vaccine is the quickest way back to normal.

ShineOn7

MadYaker wrote: »

The mutations seen so far aren’t enough to stop a vaccine from being effective. Just because you read random information somewhere doesn’t make it true. We’ll have drugs in a few months and a vaccine next year. If only one of the many drugs being trialled is effective that’s enough, but there’ll be multiple. The flu mutates every year (segmented genome) and we just come up with a new vaccine every year. Coronaviruses are different so that likely won’t be necessary. Vaccine should be effective for many years. But even if we have to make a new vaccine every year that is what will happen.

What is your source for any or all of that?

SARS 1 from 2013 still hasn't got an effective vaccine - in 17 years. My point still stands.

Why should SARS 2 (Covid) be ok to vaccinate against when they couldn't find one for SARS 1?

ShineOn7

MadYaker wrote: »

You’re right about SARS 1 having no vaccine though and yet it has been essentially eliminated or at least massively suppressed. HIV also has no vaccine but most HIV sufferers can live relatively full lives now due the quality of treatments available. There are other solutions even without a vaccine but a vaccine is the quickest way back to normal.

SARS 1 is like a mild cold compared to SARS 2 (Covid). It was reletively easily eliminated, it didn't spread anywhere near as much as Covid. There's no comparison

As for HIV? Seriously?

When could you last catch HIV by someone coughing on you or you putting your hand on the wrong surface?

trapp

ek motor wrote: »

How does any of that 'beat' this virus ? This virus is already absolutely flooring even relatively young and healthy people. The only way this virus will be 'beaten' is with a vaccine or totally effective anti viral drugs.

Dear oh dear oh dear my poor man.

Go and find your tinfoil.

The percentage of young and healthy people who have dies is absolutely tiny.

My goodness it's a long time since I've seen such nonsense my poor friend.

trapp

ek motor wrote: »

I'd imagine a dramatically reduced life expectancy, permanent social distancing of some sort, PPE becoming compulsory. The end of life as we knew it. Possibly an extinction level event, if reinfection proves possible and deadlier due to already damaged organs.

I hope there's a vaccine or effective treatment for this soon.

I'd strongly advise taking a walk in the fresh air my poor friend.

These claims are incredibly outlandish nonsense on a great, massive napoleonic scale.

I could explain the reality to you but what's the point.

Dear oh dear oh dear.

ShineOn7

trapp wrote: »

Dear oh dear oh dear my poor man.

Go and find your tinfoil.

The percentage of young and healthy people who have dies is absolutely tiny.

My goodness it's a long time since I've seen such nonsense my poor friend.

trapp wrote: »

I'd strongly advise taking a walk in the fresh air my poor friend.

These claims are incredibly outlandish nonsense on a great, massive napoleonic scale.

I could explain the reality to you but what's the point.

Dear oh dear oh dear.

Your condescending attitude really isn't helping. Covid is indeed flooring young people. It's putting fit people who've done Triathlons and fitness instructors in the fúcking ICU!

Dear oh dear oh dear oh dear oh dear oh dear. Etc

trapp

ShineOn7 wrote: »

Your condescending attitude really isn't helping. Covid is indeed flooring young people. It's putting fit people who've done Triathlons and fitness instructors in the fúcking ICU!

Dear oh dear oh dear oh dear oh dear oh dear. Etc

The exceptions that prove the rule my poor man.

All of the evidence and experts agree that covid in the majority of cases is a serious illness for our older population or less often younger people with poor health or who are quite ill already.

It doesn't put young healthy people in the icu my poor man.

I suggest you remove your tinfoil and stop scarmonegering.

We're all aware of the seriousness of the virus.

However making it worse than it is is quite unneccessary my man.

An extinction level event as you and another poor man suggested is napoleonic hyperbolic nonsense on an incredible scale.

MadYaker

ShineOn7 wrote: »

What is your source for any or all of that?

SARS 1 from 2013 still hasn't got an effective vaccine - in 17 years. My point still stands.

Why should SARS 2 (Covid) be ok to vaccinate against when they couldn't find one for SARS 1?

SARS 1 didn't cause a pandemic so a vaccine wasn't needed. A vaccine for SARS 1 actually was in the works but it was shelved when the epidemic subsided. It took them 4 months to sequence the SARS 1 genome, were much faster at that today and as I type there about 60 different research groups working on a vaccine for SARS 2. Trials have already started https://www.bbc.com/news/health-52394485

Sorry to burst your bubble

MadYaker

I'm not familiar with the south china morning post but there's good basic info in this article https://www.scmp.com/news/china/science/article/3051853/there-was-no-vaccine-sars-or-mers-will-there-be-one-new

ShineOn7

trapp wrote: »

The exceptions that prove the rule my poor man.

It doesn't put young healthy people in the icu my poor man.

However making it worse than it is is quite unneccessary my man.

Lol, I'm not engaging with you in any more debate on this.

I just remembered you're "that loon who started that 2am thread one night screaming for lockdowns to be lifted"

I was worried for you that night. Now I just feel pity

ShineOn7

MadYaker wrote: »

SARS 1 didn't cause a pandemic so a vaccine wasn't needed. A vaccine for SARS 1 actually was in the works but it was shelved when the epidemic subsided. It took them 4 months to sequence the SARS 1 genome, were much faster at that today and as I type there about 60 different research groups working on a vaccine for SARS 2. Trials have already started https://www.bbc.com/news/health-52394485

Sorry to burst your bubble

No "bubble" bursted here. That's good news, if the trials make it outside of a lab (the vast majority of them don't)

The toxicity from some posters is quite something considering what we're talking about

trapp

ShineOn7 wrote: »

Lol, I'm not engaging with you in any more debate on this.

I just remembered you're "that loon who started that 2am thread one night screaming for lockdowns to be lifted"

I was worried for you that night. Now I just feel pity

Given the impact of the lockdown on my mental health as you saw that night I'd have serious concerns about the effect on other poor people who would not be as strong as me.

To debate your point one final time my poor man.

Do you really beleive, against all the evidence, that covid impacts on young people as much as our older population??

Awaiting your response in earnest my good man.

MadYaker

ShineOn7 wrote: »

No "bubble" bursted here. That's good news, if the trials make it outside of a lab (the vast majority of them don't)

The toxicity from some posters is quite something considering what we're talking about

I should say those trials are on humans by the way, I guess that's what you mean by "out of the lab"? It's still going to be next year though most likely, life can't really get back to normal until we have a vaccine unfortunately.

I believe the Chinese have started human trials also though I can’t find a source for that now. With the sheer number of vaccines currently being worked on we’ll probably end with a few that are effective.

kravmaga

The chan chan man wrote: »

The common cold is also a coronavirus, there has been no prevention or cure for this for centuries. So what if there’s no cure for Covid-19? Do we stay on lockdown for life and watch our economies and mental states dwindle, or just accept that grandma’s gotta go?

Well there is still no cure or vaccine for HIV/Aids, that,s around since the early to mid 1980's.

patnor1011

ek motor wrote: »

How does any of that 'beat' this virus ? This virus is already absolutely flooring even relatively young and healthy people. The only way this virus will be 'beaten' is with a vaccine or totally effective anti viral drugs.

There will be no vaccine, not my words but people in the field said so.
Define "relatively young and healthy". Data show that 90% of death are over 80 and immunocompromised people with other underlying health issues. So "relativey healthy and young" is quite subjective. You are healthy or you are not.
Antiviral drugs may be found which will work against this virus but your own immune system beating it with ease is far better option.
There is no miracle pill for everything no matter how hard do you wish for it to be truth.

patnor1011

ShineOn7 wrote: »

Your condescending attitude really isn't helping. Covid is indeed flooring young people. It's putting fit people who've done Triathlons and fitness instructors in the fúcking ICU!

Dear oh dear oh dear oh dear oh dear oh dear. Etc

That fitness instructor or soccer coach or young nurse which are oftem netioned as example were found to have undiagnosed serious issues. In other words they thought they are healthy but they were not.

hmmm

Merck CEO being interviewed today was emphatic - "there is ample reason to be optimistic that we will find either a treatment or a prevention". Merck have been responsible for 5 out of 9 vaccines approved for new diseases in past 25 years.

patnor1011

MadYaker wrote: »

SARS 1 didn't cause a pandemic so a vaccine wasn't needed. A vaccine for SARS 1 actually was in the works but it was shelved when the epidemic subsided. It took them 4 months to sequence the SARS 1 genome, were much faster at that today and as I type there about 60 different research groups working on a vaccine for SARS 2. Trials have already started https://www.bbc.com/news/health-52394485

Sorry to burst your bubble

SARS1 vaccine was not shelved because epidemic subsided. On the contrary there is few of them but none approved for humans and even those available for livestock are not being used as they caused more complications when used. A lot of papers explaining this. Rushed science is not always good, same thing happened when swine flu vaccine was rushed and caused complications in recipients.

ShineOn7

So if the posts on here and other threads are correct:

• No Immunity is coming
• No vaccine is coming. If it does, it wont work
• It has about a 1% mortality rate
• 50/60% of the world's population will get it

Meaning 1% of 4 Billion will die

And to think, I nicknamed Sky News "Gloom Porn"

This place is Sky News in forum form

CelticRambler

ShineOn7 wrote: »

So if the posts on here and other threads are correct:

• No Immunity is coming
• No vaccine is coming. If it does, it wont work
• It has about a 1% mortality rate
• 50/60% of the world's population will get it

Meaning 1% of 4 Billion will die

And to think, I nicknamed Sky News "Gloom Porn"

This place is Sky News in forum form

You're conflating points three and four. 1% of those diagnosed with symptomatic infection risk death (in the absence of effective treatment, which is only the current status and changing as scientists with real, practical experience get a chance to work on the problem); out of the 20-60% of the world's population that contract the virus, possibly as many as 80% will not become symptomatic, or not realise that they are symptomatic.

So more like 0.5% of 2 billion at risk, 80-90% of whom will be able to leave hospital after medical treatment.

Atlantic Dawn

ShineOn7 wrote: »

So if the posts on here and other threads are correct:

• No Immunity is coming
• No vaccine is coming. If it does, it wont work
• It has about a 1% mortality rate
• 50/60% of the world's population will get it

Meaning 1% of 4 Billion will die

And to think, I nicknamed Sky News "Gloom Porn"

This place is Sky News in forum form

Additionally every single person on the planet now will at some stage in their life die.

DeVore

There is no immunity or vaccine for HIV/Aids. Yet people (and society) live full and fruitful lives with it in the populace through anti-retrovirals and treatment.

Mitigating treatments may yet be found to curb the death rate and maintain health in the affected. Perhaps drugs to dampen the cytokine storm response that does much of the damage (a response from our own immune system).

Right now we dont know that ANY of the doomsday scenarios are going to come to pass (no vaccine, no treatment, no immunity etc). Lets not worry about what may or may not happen, we have enough to worry about with what is ACTUALLY happening.

Stay home. Wash your hands.

CelticRambler

DeVore wrote: »

Perhaps drugs to dampen the cytokine storm response that does much of the damage (a response from our own immune system).

No "perhaps" about it. A French group, working across multiple hospitals, has identified an existing monoclonal antibody that does just that, in a properly run randomised trial. Results being peer-reviewed as we speak ...

Gynoid

DeVore wrote: »

There is no immunity or vaccine for HIV/Aids. Yet people (and society) live full and fruitful lives with it in the populace through anti-retrovirals and

Yes. But seriously how can using the example of the mitigation of HIV by retrovirals etc be overly comforting re Covid? I would not like to be on retrovirals for life or continue to pose a risk to close contacts if my viral load is too high. With HIV one can take very reasonable and easy precautions to avoid contracting it - with Covid being transmissable by aerosol, then not so much.
I hope cures are found. Personally I am using Vit D, occasional doses of echinecea augustifolia and cardiovascular exercise as hopeful preventatives. But in the meantime I think we have to fully accept that a really sh1tty, horrible, and serious thing has suddenly happened in the world. It requires patient endurance as well to wait and see what will happen. Patient endurance, it seems from some posts I see on boards, is not a quality that has been widely enough inculcated in our present civilisation.

TheIrishGrover

It is actually an interesting question. I mean, as so many have said, the world does need to get back to business and as normal as possible as soon as possible. Personally I don't think they will find a vaccine (I have no concrete basis for that feeling, it's just a belief).

CURRENTLY it seems that contracting/overcoming C-19 does NOT give you immunity so it does seem there is some variation out there.

I think (And, again, no scientific basis) what will happen will be:

• Restrictions will be lifted (Apart from pubs/restaurants/cinema etc). There will be a spike which will flatten in about a month as offices open, people mingle closer again.
• About a month after leveling off/ dropping midway between spike and Pre C19 levels of mortality (About the best we can hope for I believe. Prob optimistic) pubs/restaurants/cinemas etc will open.
• LARGE spike as pubs/restaurants will be jammers. Will level off/ drop a bit after another 6 weeks.
• I believe that this is going to be basically the new norm and something we are going to have to live with (No pun intended).

Obviously if this was the case then hospitals/medical institutions would need increased funding, hospitals, treatment research. Overall daily death rates will probably be 50% higher than Pre-Covid times, people will need to pay more attention to illnesses, especially the vulnerable but I think eventually we will need to go back to the office, will need to travel internationally, will need to mingle with friends and strangers and yes, will need to go back to pubs and restaurants and football matches and travel abroad for holidays. As a scociety of social animals social interaction is essential

Of course I hope I'm wrong. Every single one of us has loved ones who are in the danger zone and this will eventually wreak havoc in poorer nations/regions like Africa and South America but I just don't see a vaccine coming. Not for a couple of ears at the very least.

stephenjmcd

TheIrishGrover wrote: »

It is actually an interesting question. I mean, as so many have said, the world does need to get back to business and as normal as possible as soon as possible. Personally I don't think they will find a vaccine (I have no concrete basis for that feeling, it's just a belief).

CURRENTLY it seems that contracting/overcoming C-19 does NOT give you immunity so it does seem there is some variation out there.

I think (And, again, no scientific basis) what will happen will be:

• Restrictions will be lifted (Apart from pubs/restaurants/cinema etc). There will be a spike which will flatten in about a month as offices open, people mingle closer again.
• About a month after leveling off/ dropping midway between spike and Pre C19 levels of mortality (About the best we can hope for I believe. Prob optimistic) pubs/restaurants/cinemas etc will open.
• LARGE spike as pubs/restaurants will be jammers. Will level off/ drop a bit after another 6 weeks.
• I believe that this is going to be basically the new norm and something we are going to have to live with (No pun intended).

Obviously if this was the case then hospitals/medical institutions would need increased funding, hospitals, treatment research. Overall daily death rates will probably be 50% higher than Pre-Covid times, people will need to pay more attention to illnesses, especially the vulnerable but I think eventually we will need to go back to the office, will need to travel internationally, will need to mingle with friends and strangers and yes, will need to go back to pubs and restaurants and football matches and travel abroad for holidays. As a scociety of social animals social interaction is essential

Of course I hope I'm wrong. Every single one of us has loved ones who are in the danger zone and this will eventually wreak havoc in poorer nations/regions like Africa and South America but I just don't see a vaccine coming. Not for a couple of ears at the very least.

Well put, I'm quite inclined to agree, while I do hope there is eventually a vaccine its potentially well into the future. we cant continue to live under restrictions indefinitely and social isolation isn't an option indefinitely.

There will have to be a point where people are more conscious of their health and learn to live alongside the virus. There will be a stigma surrounding anyone that goes to an event that has a cough or even the common cold, automatically people will keep their distance, the solution you isolate for the 2 weeks if you have even the common cold. It'll become socially unacceptable to be out and about when your even mildly unwell

Hmmzis

The comparison to HIV is a bit disingenuous at best. The two viruses work and attack the human body in vastly different ways. There are antibodies produced in the body against HIV, but the trouble with that virus is that it mutates very quickly while inside the body.
SARS-cov-2 doesn't do anything like that, otherwise no person would have recovered from it.

Regarding immunity, the WHO have backpedalled their rather misleading tweet:

https://twitter.com/WHO/status/1254160937805926405

CelticRambler

Hmmzis wrote: »

Regarding immunity, the WHO have backpedalled their rather misleading tweet

They haven't backpedalled, they've just tried to rephrase a statement made using a typically scientific way of talking into language that can be correctly interpreted by social media, journalists with short attention spans and Russian bots.

There's an enormous gulf between the reality of "the scientific process" as it relates to contagious disease (sources of contagion, rates of infection, development and testing of vaccines and treatments) and what the modern public wants and expects ... and the end point is definitely not like anything you'll see in any Hollywood movie.

So the OP's question is essentially rhetorical: what if there is no cure? Well, there will be a cure, because as scientists, we will keep plugging away at the problem until one is found. When that happens remains to be seen - but it won't be until politicians stop wasting money on pointless arse-covering excercises with no hope of success.

Will there be a cure? Yes, it's already on the way.

Will there be a reliable, effective vaccine? No, because it'll be a lot cheaper, using existing medicines, to cure the few people who get really sick, compared to the cost of developing and administering a vaccine to millions of people who don't need it.

Will we ever have reliable antigen tests? Yes - we already do.
- Is it worth being tested? Yes, no, maybe ... probably not for most people, because what are you going to do when you know the result?

Will we ever have reliable antibody tests? Yes - we already do.
- Is it worth having more and faster tests? Yes, no, maybe ... almost certainly not for most people, because what are you going to do when you know the result?

ek motor

patnor1011 wrote: »

There will be no vaccine, not my words but people in the field said so.

Where did you read that ?

MadYaker

patnor1011 wrote: »

SARS1 vaccine was not shelved because epidemic subsided. On the contrary there is few of them but none approved for humans and even those available for livestock are not being used as they caused more complications when used. A lot of papers explaining this. Rushed science is not always good, same thing happened when swine flu vaccine was rushed and caused complications in recipients.

Did you even read the BBC article I linked? The group from Oxford have already started human trials of the Coronavirus vaccine.

Hmmzis

Some perspective of the original SARS vaccine developments:

https://wwwnc.cdc.gov/eid/article/11/7/pdfs/05-0219.pdf

- Inactivated virus versions didn't prove to be particularly safe in animal trials
- Full length S protein versions were very effective in animals, but could lead to adverse effects if subject was infected with related coronaviruses
- RBD versions seemed to be the best approach inducing large amounts of neutralising antibodies and showing no adverse effects in animals

CelticRambler

ek motor wrote: »

patnor1011 wrote: »

There will be no vaccine, not my words but people in the field said so.

Where did you read that ?

Can't speak for patnor1011, but as one of the "people in the field" I can confirm that there are lots of us saying so. It's a simple question of biology and economics:

- do members of the coronavirus family of viruses provoke useful immunity? No
- is it likely that SARS-CoV-2 will provoke useful, lasting immunity? No
- will a vaccine change the fact that coronavirus-induced illness is caused by an over-reaction of the patient's immune system? No.
- is it as likely that a SARS-CoV-2 vaccine will trigger as many cases of Covid-19 as the virus itself? Yes
- is it likely that a potential vaccine will make it through development, clinical trials and regulation before either (a) the virus fades into the background due to containment measures; or (b) a useful treatment protocol for severe cases is identified and made readily available? No.
- is any pharma company going to invest in a SARS-CoV-2 vaccine, knowing that it's likely to be both ineffective and unnecessary? No.

As I mentioned on another thread, contrary to "popular opinion" there's very little money in vaccines for Big Pharma, so they've been opting out of vaccine research and production over the last couple of decades, to the extent that we're starting to see occasional problems with the supply of the "old reliables". Vaccines are now a loss-leader for most manufactuers, and a now-you-see-it-now-you-don't disease doesn't warrant the lab space needed; not when you can make millions from treatments for obesity, diabetes, heart disease and cancer.