COVID-19: Vaccine and testing procedures Megathread Part 2 [Mod Warning - Post #1]

Chris_5339762

weisses wrote: »

That's why you vaccinate the people who are in the most danger of getting the virus and transmitting it ... Admin staff don't fall into that category

Admin staff should not be a day 1 priority ..... simples

Perhaps not Day 1, but by "admin staff" they could mean the people on the desk meeting patients and checking them in. They meet more patients than the doctors, nurses and all of those so I'd give it to them fairly quickly.

speckle

speckle wrote: »

Thats great for your uncle who is 90... but does he understand he is not protected yet if he just got the first dose?

The first dose does protect. The second ups the effectiveness.

speckle

Water John wrote: »

His immunity will begin to kick in at about 10 days. I don't know how much.

Thats why I was worried ..sounds like just a week later he was partying

Folks I really think we need to explain the above to our elders and get the word out..the last thing we want for them thinking the are totally safe the next day after the first dose and ending up getting ill. This is why going through the paperwork pre vaccination is so important especially with older high risk people and those who do not read and write.. which we still have high numbers of in this country.

speckle

[Deleted User] wrote: »

The first dose does protect. The second ups the effectiveness.

Not straight away... and remember the immune response in very old people is not as strong.. they as far as I can remeber did not have 80+ year olds in the original trial.

Stark

D.Q wrote: »

Ideally that misery merchant George Lee should have to report on the amount vaccinated every day.

Well the numbers will be small enough to add to the misery for a few months. "We're up to 0.001% of population, woohoo".

Stark

Stark wrote: »

Well the numbers will be small enough to add to the misery for a few months. "We're up to 0.001% of population, woohoo".

Given that’s only 50 people I would say we are well past that number. Also, given people aren’t “vaccinated” fully until they get the second dose, keeping league tables may be good for publicity but they won’t actually mean anything substantial until we are at least 3 weeks in

ACitizenErased

Not sure if anyone posted this but the Argentinians have approved the Oxford vaccine.

ACitizenErased

ACitizenErased wrote: »

Not sure if anyone posted this but the Argentinians have approved the Oxford vaccine.

Good stuff, that's 3 approved for them now.

Doesn't look like AstraZeneca's initial production numbers are anywhere near what had been promised. Only 540,000 being made available to the UK for next week but 2 million a week by mid January.

Cork2021

[Deleted User] wrote: »

Doesn't look like AstraZeneca's initial production numbers are anywhere near what had been promised. Only 540,000 being made available to the UK for next week but 2 million a week by mid January.

That’s not bad, they’ll be out of this by April the way they’re going

Water John

Deleted User wrote: »

Doesn't look like AstraZeneca's initial production numbers are anywhere near what had been promised. Only 540,000 being made available to the UK for next week but 2 million a week by mid January.

Think that vaccine can ramp up quite quickly to big numbers.

Cork2021

Cork2021 wrote: »

That’s not bad, they’ll be out of this by April the way they’re going

Yeah it's okay, but a few weeks ago it was being reported the UK already had 4 million doses and another 15 million were ready. Doesn't seem to be the case. At least they're getting started with it.

ACitizenErased

Deleted User wrote: »

Yeah it's okay, but a few weeks ago it was being reported the UK already had 4 million doses and another 15 million were ready. Doesn't seem to be the case. At least they're getting started with it.

That's because the UK's approval means every delivery has to be certified individually. That's why they approve so quickly.

ACitizenErased

ACitizenErased wrote: »

That's because the UK's approval means every delivery has to be certified individually. That's why they approve so quickly.

I wouldn't have thought that would cause any particular delay. Reading that one of the issues is actually getting the stuff into vials at the manufacturing stage.

ShineOn7

The latest from John

He's very positive about the vaccines here

https://www.youtube.com/watch?v=8Pj4_aK-j8I

Astra Zeneca have submitted the full data package to the EMA

https://www.livemint.com/news/world/oxford-covid-19-vaccine-astrazeneca-applies-for-european-regulator-s-approval-11609348915265.html

Edit: as per posts below, above may not be true.

ACitizenErased

Good vaccine article here by Derek Lowe, he's usually fairly spot on. He has some pretty scathing criticism of AstraZeneca which possibly explains why the EMA is so reluctant right now.

https://blogs.sciencemag.org/pipeline/archives/2020/12/30/vaccine-roundup-late-december

ACitizenErased

For people who think we're slow:
The Netherlands are to wait for AZ/Oxford to be approved.

https://twitter.com/annaholligan/status/1344405690966802433?s=20

ACitizenErased

Deleted User wrote: »

Astra Zeneca have submitted the full data package to the EMA

https://www.livemint.com/news/world/oxford-covid-19-vaccine-astrazeneca-applies-for-european-regulator-s-approval-11609348915265.html

I'm not sure that's true. The article contradicts itself and no others news agency is reporting it right now.

stephenjmcd

[Deleted User] wrote: »

Astra Zeneca have submitted the full data package to the EMA

https://www.livemint.com/news/world/oxford-covid-19-vaccine-astrazeneca-applies-for-european-regulator-s-approval-11609348915265.html

Interesting because that goes against what the EMA said only a few hours ago.


"So far, some evidence has been assessed on safety and efficacy coming from a pooled analysis of interim clinical data from four ongoing clinical trials in the UK, Brazil and South Africa. The latest clinical package was received on 21 December and is currently being assessed. CHMP has already assessed data from laboratory studies (non-clinical data) and is currently assessing data on the vaccine’s quality (on its ingredients and the way it is manufactured).

Additional scientific information on issues related to quality, safety and efficacy of the vaccine is deemed necessary to support the rigour required for a conditional marketing authorisation and this has been requested from the company."

https://twitter.com/EMA_News/status/1344328548543291394?s=19

namloc1980

Article here about the AZ vaccine not going to get the go ahead in the US until at least April. They're not convinced yet about it's efficacy. More trials ongoing there. The development of this vaccine has been less than smooth.

https://www.politico.com/news/2020/12/30/astrazeneca-vaccine-april-452371

ACitizenErased

ACitizenErased wrote: »

Good vaccine article here by Derek Lowe, he's usually fairly spot on. He has some pretty scathing criticism of AstraZeneca which possibly explains why the EMA is so reluctant right now.

https://blogs.sciencemag.org/pipeline/archives/2020/12/30/vaccine-roundup-late-december

I'd agree it's been very messy and the lack of structure to some aspects of their trial were a bit shocking (half doses by mistake, followed by full doses anywhere from 4 to 16 weeks later, initial plans single dose... all very confusing). Probably highlights why combining phase 2 and 3 isn't best practice.

But at this point, we know it's at least 60% efficacious and we know it's safe, that surpasses the initial criteria for the regulator to approve and I think that should be the defining aspect for the EMA and they need to get their review done ASAP, the trial wasn't run as well as others but if they have the data they need get on with it.

stephenjmcd

namloc1980 wrote: »

Article here about the AZ vaccine not going to get the go ahead in the US until at least April. They're not convinced yet about it's efficacy. More trials ongoing there. The development of this vaccine has been less than smooth.

https://www.politico.com/news/2020/12/30/astrazeneca-vaccine-april-452371

Theres a difference here though, the FDA will not accept data from trials in other countries, hence a new trial was required to be run in the USA, this is whats causing the delay. They won't have the readout for a while yet on that trial,its fully enrolled and underway

landofthetree

If the USA,Israel and the UK are out of this first I can wait to see the Irish times meltdown.

billyhead

landofthetree wrote: »

If the USA,Israel and the UK are out of this first I can wait to see the Irish times meltdown.

You can't compare the UK and US with us. Huge population difference and to administer the vacine to.

Gael23

namloc1980 wrote: »

Article here about the AZ vaccine not going to get the go ahead in the US until at least April. They're not convinced yet about it's efficacy. More trials ongoing there. The development of this vaccine has been less than smooth.

https://www.politico.com/news/2020/12/30/astrazeneca-vaccine-april-452371

Well hopefully that leads to greater supply for everyone else

Cork2021

Just looking through Twitter and just what’s being said about the EMA and Oxford is that the EMA wants more data on the safety and efficacy of the vaccines even after receiving all data from AstraZeneca
You’ll need to translate this. Theres more of the same from Belgium Holland Germany as you go through. I searched ema Oxford and these all popped up.

https://twitter.com/sinembargomx/status/1344390301943738368?s=21

stephenjmcd

List of nursing homes included in the initial rollout for next week.

Nationwide from 11th.

https://amp.independent.ie/irish-news/revealed-nursing-homes-to-receive-first-covid-19-vaccinations-in-soft-roll-out-next-week-39915403.html?__twitter_impression=true

marno21

If Janssen come through with an effective single shot vaccine in the first 2 months of this year we won't need Oxford/AZ. There is an awful lot of faffing about with that vaccine at the minute and it would be better if resources were driven towards something with proven results.

If we do get Janssen in the first months of the year, single shot we'll have this addressed in mere months.

Anyone know the latest timelines for this vaccine?

stephenjmcd

Cork2021 wrote: »

Just looking through Twitter and just what’s being said about the EMA and Oxford is that the EMA wants more data on the safety and efficacy of the vaccines even after receiving all data from AstraZeneca
You’ll need to translate this. Theres more of the same from Belgium Holland Germany as you go through. I searched ema Oxford and these all popped up.

https://twitter.com/sinembargomx/status/1344390301943738368?s=21

All here, last data packet EMA got was 21stDec.

"Additional scientific information on issues related to quality, safety and efficacy of the vaccine is deemed necessary to support the rigour required for a conditional marketing authorisation and this has been requested from the company."

So they've not supplied all the requested data, there also is the matter that they haven't applied for CMA.

I note that the Canadian health authorities have also now asked for essentially the same information that the EMA is asking for. Regulators seeking clarification on a few fronts.

https://twitter.com/EMA_News/status/1344328548543291394?s=19