Vaccine Megathread No 2 - Read OP before posting

Charles Babbage

New study in Scotland
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01358-1/fulltext
https://www.bloomberg.com/news/articles/2021-06-14/delta-variant-doubles-risk-of-covid-hospitalization-in-study


The BioNTech/Pfizer jab was 79 per cent effective in stopping infection from the Delta variant with 92 per cent effective against the Alpha variant, while the Oxford/AstraZeneca vaccine was 60 per cent effective against Delta as against 73 per cent against Alpha.

Hospitalisation risk increased 85 per cent for the Delta strain, but fully vaccinated people and those more than four weeks after their first dose benefited from a 72 per cent reduction in the risk of hospital admission compared to those who have not been inoculated.

This is being reported as the risk of being hospitalised doubling, although the vaccines are still pretty effective. I could still see a role for boosters tailoured to the variants, especially for the older half of the population.

xboxdad

Vaccinated30 wrote: »

they lick the windows of Dublin bus

LOL, I'd only do that from the outside

Eod100

is_that_so wrote: »

AZ is really for second shots and the very small J&J totals look like it will just be over 50s.

Thanks. Makes sense. Saw pharmacies getting 60,000 J and J to distribute alright.

is_that_so

CruelSummer wrote: »

So many people in their 30’s are getting contacted by GP’s with ‘spare’ vaccine doses…really wish they’d open up 35-39, at least to avoid more people trying to get it done through the back door of the local who the GP knows system.

Lots of AZ & Pfizer second doses to do in MVCs, so it makes sense to hold off for a little bit longer on the next age group.

Cork2021

https://twitter.com/coronavirusgoo1/status/1404486361172922368?s=21

Eod100

Eod100 wrote: »

Haven't been following thread lately so apologies if covered already but has there been any official announcement yet from NIAC or HSE on what vaccines people under 50 will be getting? Guess decision would be needed fairly soon with registering of people in 40s.

Registering? They are vaccinating the low 40’s. Moderna and Pfizer BioNtech seems to be it

https://www.independent.co.uk/news/health/covid-vaccine-hospitalisation-delta-variant-b1865685.html

Good data on delta.

Two doses of pfzier risk of hospitalisation 96% reduced. Two doses of astra risk of hospitalisation 92% reduced. Astra figures may rise as slower to reach optimal protection.

Unvaccinated twice as likely to be hospitalised with Delta than Alpha.

stephenjmcd

As expected AZ numbers better than first reported a few weeks ago.

https://twitter.com/jburnmurdoch/status/1404494080244162562?s=19

stephenjmcd

stephenjmcd wrote: »

As expected AZ numbers better than first reported a few weeks ago.

https://twitter.com/jburnmurdoch/status/1404494080244162562?s=19

Illustrates why UK and ireland are pushing for those second doses especially for AZ.

Eod100

[Deleted User] wrote: »

Registering? They are vaccinating the low 40’s. Moderna and Pfizer BioNtech seems to be it

Fair shout

[Deleted User]

[Deleted User] wrote: »

Illustrates why UK and ireland are pushing for those second doses especially for AZ.

It kind of highlights that we may need to consider giving over 60s an mRNA dose asap, they're at a big risk of hospitalisation with no vaccine, and although that 92 figure is great against hospitalisation, I'm sure it drops for older groups, so is unlikely to be the efficacy figure for that age group.

[Deleted User]

[Deleted User] wrote: »

It kind of highlights that we may need to consider giving over 60s an mRNA dose asap, they're at a big risk of hospitalisation with no vaccine, and although that 92 figure is great against hospitalisation, I'm sure it drops for older groups, so is unlikely to be the efficacy figure for that age group.

Illustrates the opposite.

2 doses of AZ is nearly as effective as 2 doses of pfzier re hospitalisation.

Alot of younger people have zero protection (under 40s).

In your scenario:

Many AZ doses will go to waste that are proven to increase protection.
Many younger people will go longer completely unprotected.
Greater opportunity for spread in the weeks and months ahead as less percentage of population vaccinated with one and two doses.
Mixing vaccines has less trial data than two doses.
NIAC love data to make decisions. This is good data for them to proceed as is.

larchielads

Theyd just wanna hurry on now and open up the next age group im gettin impatient here.

larchielads

larchielads wrote: »

Theyd just wanna hurry on now and open up the next age group im gettin impatient here.

I'm 40 and I haven't even gotten an appointment yet. You'll be waiting a while.

Paranoid Mandroid

larchielads wrote: »

Theyd just wanna hurry on now and open up the next age group im gettin impatient here.

ah here, Veruca Salt here



if you don't get the reference, you'll be ages waiting, if you do it won't be long

RavenBea17b

Woody79 wrote: »

https://www.independent.co.uk/news/health/covid-vaccine-hospitalisation-delta-variant-b1865685.html

Good data on delta.

Two doses of pfzier risk of hospitalisation 96% reduced. Two doses of astra risk of hospitalisation 92% reduced. Astra figures may rise as slower to reach optimal protection.

Unvaccinated twice as likely to be hospitalised with Delta than Alpha.

Plus the interesting review of benefits of T cell anti-bodies production of viral vector vaccines (AZ & Janssen) vs mRNA vaccines Pfizer & Moderna.
Mixing maybe.

RavenBea17b

RavenBea17b wrote: »

Plus the interesting review of benefits of T cell anti-bodies production of viral vector vaccines (AZ & Janssen) vs mRNA vaccines Pfizer & Moderna.
Mixing maybe.

Probably in time for boosters etc.

I personally wouldnt want to do it now.

The process is rushed enough for alot of people without doing a sort of live trial.

deeperlearning

Cork2021 wrote: »

https://twitter.com/coronavirusgoo1/status/1404486361172922368?s=21

So those who are vaccinated with AZ are twice (8%) as likely to end up in hospital that those who received Pfizer (4%).

larchielads

Paranoid Mandroid wrote: »

ah here, Veruca Salt here



if you don't get the reference, you'll be ages waiting, if you do it won't be long

Ha ha :pac:

deeperlearning

deeperlearning wrote: »

So those who are vaccinated with AZ are twice (8%) as likely to end up in hospital that those who received Pfizer (4%).

Talk about glass half empty.

But it has 92% protection from hospitalisation.

Also optimal AZ protection builds over 4-5 weeks after each dose.

Pfzier 2-3 weeks after each dose.

More than likely AZ is higher over a longer time period and sample size.

Also when you are down to those small numbers its likely only the extremely
vulnerable who would be hospitalised after two doses.

deeperlearning

Why does the UK seem to be the only western country badly affected by the Delta variant?

Is it an inherent weakness in the AstraZeneca vaccine?

Cork2021

China have released vaccine
numbers!!!

https://twitter.com/redouad/status/1404473479127343112?s=21

OwlsZat

deeperlearning wrote: »

So those who are vaccinated with AZ are twice (8%) as likely to end up in hospital that those who received Pfizer (4%).

The Israel daily cases make a very strong advert for Pfizer. England's AZ advert not so much.

Goldengirl

deeperlearning wrote: »

Why does the UK seem to be the only western country badly affected by the Delta variant?

Is it an inherent weakness in the AstraZeneca vaccine?

Stretching dosage gaps in a bid to vaccinate more people quickly ...
Not restricting travel in from India in a more timely fashion...
Opening up too quickly .especially indoors ..
Relying on populist measures instead of " an abundance of caution" ...
Doing the opposite to everyone else!

deeperlearning

deeperlearning wrote: »

Why does the UK seem to be the only western country badly affected by the Delta variant?

Is it an inherent weakness in the AstraZeneca vaccine?

Strong links to India from North of England and allowed it strong foothold in country.

Opened up country too quickly with nobody under 50 vaccinated.

Many people with only one dose vaccine.

Infection rates among unvaccinated age groups are through the roof.

Listen to this lad if you want to see graphs of vaccinated vs. unvaccinated infections etc.

https://www.youtube.com/watch?v=OHBua3aXQ7c

An early warning for us and a good learning tool for us.

OwlsZat

OwlsZat wrote: »

The Israel daily cases make a very strong advert for Pfizer. England's AZ advert not so much.

Very simplistic analysis.

I'll give you one back:

https://www.worldometers.info/coronavirus/country/uk/

Less than 10 covid deaths a day in UK for last month out of a population of over 70 million (3 deaths reported today).

Elimination was never the goal a year ago, its impacts that count.

HIV is still with us today, but we have learned to live with it with much less harm.

Harm reduction at this stage.

bikeman1

Folks getting impatient must remember a few important things at this stage.

The 40-44 age cohort is the biggest population band in the country, and that’s after coming after the very big 45-49 band (see attachment). As a result it will seem slower.

Coming now at the same time is the first heavy batches of the 60+ AZ folks, who IMO are most vital to get their second vaccine ASAP taking the delta variant concerns.

Then we have the second dose MRNA’s coming through after the big ramp up in May.

All these give the impression of it being slower moving down the ages.

In theory the 30-34 should be lashed through as they are a smaller population base.

strongback

People in their 20's are being vaccinated by GP's as we speak.

So much for procedure and protocol.

Goldengirl

strongback wrote: »

People in their 20's are being vaccinated by GP's as we speak.

So much for procedure and protocol.

Some of those might have underlying conditions that are not obvious to the general public .
I know lots of 20 year olds that fall into that category , and they wouldn't tell their mates that that is why they are getting their shot.

Caquas

The Irish Mail’s front page story today is about those waiting for a second dose of AZ

We are the Forgotten of Vaccines

RTÉ’s Drivetime “was inundated with calls and tweets from over-60s who said they felt forgotten...

Linked to fears of the Delta variant