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The Ivermectin discussion

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Comments

  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    moonage wrote: »
    There's a debate between the author of that BMJ paper and Dr Pierre Kory, one of the leading proponents of ivermectin.

    The BMJ guy has very weak arguments and Dr Kory runs rings around him:

    The research institute where he works is funded by my favourite pharma company Merck/MSD, and others, and yet he declares no competing interests in his opinion piece.


  • Registered Users, Registered Users 2 Posts: 9,235 ✭✭✭lucernarian


    There are those who equate Ivermectin advocacy with vaccine denialists, but both they and the ones who actually are guilty of this are lacking a lot of perspective on science, evidence and empiricism.

    I think it's fair to say at this point that ivermectin deserves further study to get high quality data on its efficacy, but it's not a foregone conclusion that it clearly works.


  • Registered Users, Registered Users 2 Posts: 14,040 ✭✭✭✭Johnboy1951


    There are those who equate Ivermectin advocacy with vaccine denialists, but both they and the ones who actually are guilty of this are lacking a lot of perspective on science, evidence and empiricism.

    I think it's fair to say at this point that ivermectin deserves further study to get high quality data on its efficacy, but it's not a foregone conclusion that it clearly works.

    All indications are that it is beneficial across all stages of the disease including as a preventative.

    True, the definitive studies have not been done, and are unlikely to be done for various reasons.

    There is nothing anywhere that I have found that indicates taking Ivermectin could be harmful or have other negative effects, unless a deliberate overdose was administered.

    On the basis that it is probably beneficial and in the middle of a pandemic where emergency approval for several new vaccines has been granted, the big question remains why this drug, whose safety cannot be questioned, is not available off label to patients in Ireland for the prevention and treatment of Covid-19, as determined by the patient's doctor.


  • Registered Users, Registered Users 2 Posts: 695 ✭✭✭DaSilva


    the big question remains why this drug, whose safety cannot be questioned, is not available off label to patients in Ireland for the prevention and treatment of Covid-19, as determined by the patient's doctor.

    What makes you think it is not available off label? I'm guessing its the narrative that it is a super secret cure being suppressed by big pharma?


  • Registered Users, Registered Users 2 Posts: 14,040 ✭✭✭✭Johnboy1951


    DaSilva wrote: »
    What makes you think it is not available off label? I'm guessing its the narrative that it is a super secret cure being suppressed by big pharma?

    Nothing to do with your very weird guess.

    Have you information to show it is available?
    Have you got it?
    How would I get it if I wanted it as a preventative medicine?

    As far as I am aware,
    if a doctor believes it is appropriate to prescribe it and is happy to do, and a pharmacist is happy to dispense it, it may be possible to source an ivermectin product that is licensed in another country

    How many doctors in ROI will write a prescription for this use?
    How many pharmacists will dispense it for this purpose?

    By your question I guess you have this information.


  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    I have found a report of a doctor in Ireland willing to prescribe it off-label - Dr. Pat Morrissey in Limerick.

    https://www.irishtimes.com/news/health/gp-prepared-to-fight-hse-in-event-of-removal-over-vaccine-views-1.4486934


  • Registered Users Posts: 49 snnowwy


    There are those who equate Ivermectin advocacy with vaccine denialists, but both they and the ones who actually are guilty of this are lacking a lot of perspective on science, evidence and empiricism.
    snnowwy wrote: »
    - initially were on the hydroxy chloroquine bandwagon
    I completely ignored it. Fell for the "Orange man bad" zeitgeist and let others make up my mind for me.
    I should have dealt with that more objectively.



    According to these doctors (40:45), Hydroxy chloroquine actually was of use but has been surpassed in efficacy by Ivermectin. Shame on me for shirking my responsibility for what I think.
    It's well worth watching the whole thing for a very good example of empiricism. Full disclosure: I'm only half way in but I'm confident there wont be any suggestions of using 'eye of newt' or the likes.

    I can only hope Irish GP's come out on this doctor’s side of the science / politics gauntlet.

    I think it's fair to say at this point that ivermectin deserves further study to get high quality data on its efficacy, but it's not a foregone conclusion that it clearly works.
    On the basis that it is probably beneficial and in the middle of a pandemic where emergency approval for several new vaccines has been granted, the big question remains why this drug, whose safety cannot be questioned, is not available off label to patients in Ireland for the prevention and treatment of Covid-19, as determined by the patient's doctor.

    I agree with Johnboy. Given Ivermectin's safety profile and the immediacy of the situation, I think we could relax our standards on evidence, especially in light of how we've already done that with the vaccines.

    Nothing to do with your very weird guess.

    Have you information to show it is available?
    Have you got it?
    How would I get it if I wanted it as a preventative medicine?

    As far as I am aware,
    if a doctor believes it is appropriate to prescribe it and is happy to do, and a pharmacist is happy to dispense it, it may be possible to source an ivermectin product that is licensed in another country

    How many doctors in ROI will write a prescription for this use?
    How many pharmacists will dispense it for this purpose?

    By your question I guess you have this information.

    Whoever has it, share the wealth. Don't be holding out on us.

    Do Irish doctors have the discretion to prescribe off label?
    Does that extend to medicines approved in other countries?
    Same questions for pharmacists.
    Anyone got any links to the relevant bodies for this?


  • Administrators, Social & Fun Moderators, Sports Moderators Posts: 77,932 Admin ✭✭✭✭✭Beasty


    Cut out the discussion of how to get this stuff here. AFAIK it is not licensed as an anti-Covid drug in Ireland


  • Registered Users, Registered Users 2 Posts: 14,040 ✭✭✭✭Johnboy1951


    As I understand it, any approved drug can be prescribed off label by any doctor, if it is thought efficacious.

    Do I misunderstand the situation in Ireland?

    We all know that Ivermectin is not approved for treatment of Covid-19, but does that, in itself, prevent a doctor from prescribing it for Covid-19?

    I obviously do not think this is so.
    The difficulty therefore would be finding a doctor who will prescribe it, and subsequently a pharmacist who could obtain it and would supply it to the patient.

    That is my present view, but am very willing to reconsider it in light of good/linked information.


  • Registered Users Posts: 49 snnowwy


    That is my present view, but am very willing to reconsider it in light of good/linked information.

    +1


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  • Registered Users Posts: 49 snnowwy


    Anyone have experience of long covid?
    I've heard the most common symptom is being dismissed by your doctor. Any truth to that?

    If not, I'd be interested in what kind of treatment is standard of care in Ireland at present.


  • Registered Users Posts: 855 ✭✭✭moonage


    snnowwy wrote: »
    Anyone have experience of long covid?
    I've heard the most common symptom is being dismissed by your doctor. Any truth to that?

    If not, I'd be interested in what kind of treatment is standard of care in Ireland at present.

    I don't know what the situation in Ireland is but you may be aware of the FLCCC's management treatment for long covid, with a short course on ivermectin being the initial and primary treatment:

    https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/

    Maybe print this off and see what your GP has to say about it.


    I recently got a very small horse and got some ivermectin paste for him:
    https://www.boards.ie/vbulletin/showpost.php?p=117450970&postcount=244


  • Registered Users Posts: 49 snnowwy


    moonage wrote: »
    Maybe print this off and see what your GP has to say about it.

    That is my plan, I just wanted to get a gauge of how they'll react.
    moonage wrote: »
    I recently got a very small horse and got some ivermectin paste for him

    So you're telling me that not only do you have to put a coat on it in winter but you have to brush it's teeth as well?
    How on earth did horses survive long enough for us to domesticate them?


  • Administrators, Social & Fun Moderators, Sports Moderators Posts: 77,932 Admin ✭✭✭✭✭Beasty


    Off topic Conspiracy nonsense deleted


  • Posts: 0 [Deleted User]


    Opinion piece in the Wall Street Journal yesterday is in favour of using Ivermectin as a treatment and prophylaxis for Covid. Unfortunately there is a pay wall. Though only €2 for the first two months and you can cancel at anytime.




  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    Just for complete disclosure, one author is an economist and the other an engineer and consultant for pharma. The easiest way to sway the FDA and other regulatory bodies is to complete a trial that people don't have lots of questions about and that shows it lives up to all these claims. Oxford are doing one so it might be better to see how that pans out.



  • Registered Users Posts: 1,496 ✭✭✭fun loving criminal


    Doctors cannot prescribe something thats not available. Look at the hpra website. Do a search for ivermectin under the medicines section, medicine section is for humans.

    The only authorisation is for two creams. That is what is available as ivermectin for human use in Ireland. Doctors cannot prescribe this for off-label use as it's a cream that is used on the skin. This cannot be ingested.



  • Posts: 0 [Deleted User]


    Yes one author was a senior health economist with President Reagan’s Council of Economic Advisers. Why attack the authors? Attack the content of their opinion piece. The authors claim there is already sufficient evidence to give ivermectin emergency use autorisation.



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    And yet they are not people who decide if there is enough evidence and telling the FDA what to do will not advance that cause anyway. It's not as if they are the first to make claims like this. I genuinely don't understand the strategies of those pushing Ivermectin over the last 15 months. If they are not writing opinions, they are showing up on TV, making YouTube videos telling people how right they are or shouting that they have been muzzled and that it's all one big conspiracy.

    A much better approach would have been to produce enough data that people will not question, a large clinical trial. That is coming from Oxford. TBH, unless that reveals something spectacular you really can't see it being adopted as a widespread general treatment. Research is already moving rapidly onto specific COVID treatments and that is where regulators are looking.



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  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire



    The Irish Times reported that Dr Pat Morrissey in Limerick is prescribing Ivermectin. He is likely to be using the pre authorisation mechanism provided by the HPRA.



  • Registered Users, Registered Users 2 Posts: 5,965 ✭✭✭Wolf359f


    No doubt his licence will be suspended and he won't challenge it. Surprised he didn't partner with a witch doctor!



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire



    He partnered with Dr. Pierre Kory of the Eastern Virginia medical school and president of the Front Line Covid-19 Critical Care Alliance. The current evidence that Ivermectin has a strong safety profile and has known anti-viral properties means his licence is as safe as houses. Witch doctor? ha! - you should go back to your mud hut.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire




  • Registered Users, Registered Users 2 Posts: 5,965 ✭✭✭Wolf359f


    The same doctor promoting the same treatment as this 'doctor'

    Is this **** being peddled as well as the Anti-Vaxxers, who prey upon people who are unsure or afraid of taking a vaccine.

    It's easier or 'safer' to keep the status quo, in their minds, so they gravitate with these 'doctors'



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  • Posts: 0 [Deleted User]


    Piollaire Versus the FDA. Yeah, I think I'll go with the FDA. BTW, you okay with injecting bleach too, just checking?



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Maybe you should look at why doctors across the US are ignoring this FDA document and are prescribing Ivermectin. Don't let me stop you with the bleach.



  • Registered Users, Registered Users 2 Posts: 7,504 ✭✭✭Brussels Sprout


    Wow. You've really drank the Kool-Aid haven't you!



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Who is listening to a nutjob like that? Try to distinguish the likes of her from thoughtful people of science.



  • Registered Users, Registered Users 2 Posts: 5,965 ✭✭✭Wolf359f


    The doctor you mentioned in Ireland is cut from the same cloth as her. If there's thousands of doctors recommending their patients get vaccinated and 1 saying not to, take this worming tablet instead, after the hydroxycrap and zinc didn't turn out effective. Hey at least he didn't prescribe bleach. Then again that doesn't need a prescription.



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  • Registered Users, Registered Users 2 Posts: 16,454 ✭✭✭✭Ha Long Bay


    YouTube algorithms have a lot to answer for.

    It's the same posters who are completely against a tested safe vaccine but continue to push the horse paste as a solution to ending this pandemic.



  • Registered Users, Registered Users 2 Posts: 34,132 ✭✭✭✭listermint


    I'm not saying this poster and these doctors are dangerous. But their actions actively take lives.

    How someone sleeps soundly peddling this stuff is beyond me.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    I don't necessarily accept his other views but they are logical and reasoned unlike your one. I respect someone who is independent and goes against the herd mentality. It is of course up to you if you want to pass up on an effective therapeutic for you and your family if a worming tablet is not good enough for you.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Ha! From where I'm standing everyone else is glugging it back!



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    We're talking about Ivermectin here as a therapeutic and not as a replacement for vaccines.



  • Registered Users, Registered Users 2 Posts: 5,965 ✭✭✭Wolf359f


    So you accept the views you believe in, yeah that's a little more dangerous than following a herd mentality.

    A certain doctor once said "In one video from 2013, the doctor attributes medical conditions such as endometriosis, fibroids, and cysts to “spirit husbands”, demons that have sex with women while they sleep.

    “They are responsible for serious gynaecological problems,” Dr Immanuel said. “We call them all kinds of names—endometriosis, we call them molar pregnancies, we call them fibroids, we call them cysts, but most of them are evil deposits from the spirit husband.”

    She definitely goes against the herd mentality, so you respect her. A president suggests bleach as a cure, he went against the herd mentality, you respect him also. Plenty of serial killers have gone against the herd mentality..... shall I go on?



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire




  • Registered Users, Registered Users 2 Posts: 16,454 ✭✭✭✭Ha Long Bay


    And do you agree vaccines work and are safe and have done your part by getting jabbed to end this pandemic?



  • Registered Users, Registered Users 2 Posts: 7,504 ✭✭✭Brussels Sprout


    I believe that in decades to come they will marvel at the amount of disinformation that was allowed to freely propagate during in these, relatively, early years of the internet. Two things in particular I think are pivotal:


    1. In the pre-internet era, any message that was disseminated to the masses, via the media, was, at first, validated to ensure that it wasn't an outright lie.
    2. Conspiracy theorists, who always made up a relatively small % pf the population, were at least siloed off from each other. The internet has allowed them to find each other and amplify each other's message.


    I hope that in years to come the free reign that the social media companies have enjoyed up until now, will be as anachronistic as cigarette advertising is today.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire



    It's off topic but the vaccines are very effective at stopping serious disease, hospitalisations and death. However breakthrough infections and those who haven't been vaccinated for whatever reason could benefit from this inexpensive therapeutic.



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  • Registered Users, Registered Users 2 Posts: 16,454 ✭✭✭✭Ha Long Bay


    And have you got double jabbed to ensure we got out of this sooner rather that later.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire



    You obviously presume that I haven't, think what you want - I'm here to talk about the merits of Ivermectin.



  • Registered Users, Registered Users 2 Posts: 5,965 ✭✭✭Wolf359f




  • Registered Users, Registered Users 2 Posts: 7,504 ✭✭✭Brussels Sprout




  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire




  • Registered Users, Registered Users 2 Posts: 16,934 ✭✭✭✭astrofool


    There is 2 medicines, A and B, both off patent, can be made by anyone, both cheap, both been used in medicine for years.

    Medicine A went through a peer reviewed study, was found to be effective and is now being used, B also went through numerous studies but the results were inconclusive or the study was biased in some way, B is not being used and no major company is running further studies even though they could make a lot of money from it if it's effective.

    Do people understand why medicine A became recommended and medicine B didn't?


    Incidentally, it would be great if Invermectin was proven to work, all the Pharma companies and the generic manufacturers would start making it.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Well this shows you haven't paid any attention to the Ivermectin debate at all.



  • Registered Users, Registered Users 2 Posts: 7,504 ✭✭✭Brussels Sprout


    I'm actually surprised that there's still an active Ivermectin thread given that the original study, that supported its use, has been thoroughly debunked. I guess this is one of those things that some people will hold onto, despite no supporting evidence.



  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Now this is blatant misinformation - one study in Egypt was withdrawn and there are still 50 odd others that still stand.



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  • Registered Users, Registered Users 2 Posts: 302 ✭✭Piollaire


    Take Poster A - this poster has no idea how the economics of generic drugs work. There is no Poster B



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