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Novavax and the lack of Vaccine Choice

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Comments

  • Registered Users, Registered Users 2 Posts: 4,998 ✭✭✭fly_agaric


    Funny stuff. You'd sometimes think it was a soft drink choice, Coke vs Pepsi, Sprite vs 7up...now Pfizer vs Novovax.

    Might be a while before there are hundreds of millions of Novovax doses in the EU sitting on the shelf waiting for toddler-citizens of our nanny states to make their informed consumer choice. Your chosen vaccine is temporarily out of stock. Please don't scream and shout at the cashier and make a scene.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Good thing we don't live in a total dictatorship (yet) where people have no choice Fly, but someday the nanny state will drive rules that kick you in the gut. I hope you remember your above rant then. Typed as I get my J&J jab.



  • Registered Users, Registered Users 2 Posts: 4,998 ✭✭✭fly_agaric


    To expect to get a choice of vaccine (even extending to ones like Novavax, or perhaps Sputnik or Sinopharm etc that I remember other posters looking for) is a bit much. It is not a normal situation & these vaccines are not consumer products. I think we are quite fortunate to have any of them available in large quantities let alone a choice. The government not being able to give a choice of vaccine to people is not dictating IMO, particularly in case of Novavax (what started the thread) as it is not approved yet and has not been produced at scale.

    Congrats on getting the vaccine (and you did sort of get a [more limited] choice in any case).

    edit: I haven't been following it lately, but last I read there was no agreement between the EU and Novavax, seemed to be questions as to whether the very large quantities the EU would order (multiple hundreds of millions of doses, like the other orders) could be produced. I searched, and see there was an agreement made fairly recently - only this month https://ec.europa.eu/commission/presscorner/detail/en/IP_21_4061 and it is smaller, for 200m doses.

    edit again: Novavax, not Nov'o'vax...

    Post edited by fly_agaric on


  • Registered Users, Registered Users 2 Posts: 6,330 ✭✭✭Former Former Former


    As far as I can see, Novavax has been given to 40,000 or so people in clinical trials.

    Pfizer will have made enough vaccines for 1.5 billion people by the time Novavax hits the shelves. Why is Novavax regarded as more proven?

    And Novavax are already talking about booster shots, so I'm not sure why it's seen as a better alternative?



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Novavax and Valnera are using methods quite similar to methods used in other proven vaccines. The mRNA vaccines are using new methods, hence the levels of hesitancy in some quarters outside of the anti-vax quarters and the "just jab me I want my pub pass" crowds.



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  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Congrats on getting the vaccine (and you did sort of get a [more limited] choice in any case).

    Indeed a more limited choice, but still I felt I've made the best choice for me given the circumstances. If Moderna and Pfizer were the only options open I would be still unvaccinated. At least with a little rule-bending I am able to help achieve the objective of getting as many as possible vaccinated. If top ups are required I will once again look at the options and decide then at that point in time. Let's hope the J&J is one that doesn't require top ups, don't fancy ongoing jabs to be honest. Perhaps the Valneva one will be the jab to end all Covid19 jabs? Let's hope so.



  • Registered Users, Registered Users 2 Posts: 512 ✭✭✭dvdman1


    Less than 25% of the world population is fully vaccinated. With this in mind why would choice of vaccine even be rational....get what's offered, dont become a Google educated scientist.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    There is 10% of the world in constant hunger and starvation, with this in mind why would choice of even food be rational, let alone Irish or Scottish Whisky. Don't be a hypocrite, practice what you preach.



  • Posts: 0 [Deleted User]


    The proven technology that failed to produce a vaccine against any previous coronavirus?

    1.5billion doses of Pfizer suggests it’s pretty safe



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Do elaborate.

    Also, can you pick up next Saturdays winning lotto numbers for me when you again jump into the time travel machine that brought you to 2050 and back in order to be able to say that "it's pretty safe". Nobody knows, that is a fact. Any of the vaccines or even them all or none could lead to increased Parkinson's, Alzheimer's, etc... in many years to come. We nor the scientists can say for certain.



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  • Posts: 0 [Deleted User]


    It’s clear you have zero understanding of what vaccines do.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno




  • Registered Users, Registered Users 2 Posts: 442 ✭✭random.stranger


    This thread started with Novavax, but very valid points were made against that option, the reality is there are other options available for vaccines in the country, which could be potentially wasted, the system is already in place for distribution via pharmacies.

    Got my Janssen jab a few hours behind you, should we be feeling guilty for being self entitled ##*!s who took vaccines that would probably have otherwise been binned, while people argue against using these vaccines to avoid waste?

    There is a blind faith out there that this thing is black & white, with right & wrong answers. We are adults, we are given disclaimers to sign before taking these vaccines, where we acknowledge the risks.


    The public policy to open Janssen vaccines up only to over 50's appears to be a direct copy of German policy, Germany subsequently opened it up to all age groups. The narrative here was that it was going to be difficult to get rid of these vaccines, so the option for younger age groups to skip the queue was given if they take Janssen/AZ, I haven't seen any science to back the reasoning for this up, if anything it appears to be riskier for younger people.


    As an "amatuer google scientist" I found this "wierdo" conspiracy site outlining the risks of Janssen:

    https://www2.hse.ie/screening-and-vaccinations/covid-19-vaccine/janssen/side-effects/

    Very unusual blood clots

    "Very rarely, 1 in 300,000 people may develop very unusual blood clots with low platelets. 1 in 10 of these people may die.

    The risk of this very rare condition is higher in younger people."

    I am a lot more comfortable taking a 1 in 3 million risk than risking an mRNA vaccine.

    Post edited by random.stranger on


  • Posts: 0 [Deleted User]


    Give billions of people an injection of saline and some will die. Nothing is 100% safe. Hell of a lot safer than the virus, in all age groups.

    And it’s not serious in kids, just like some of the other conditions we already vaccinate for in children.



  • Posts: 0 [Deleted User]


    I am sure there is evidence of the increased risk with the mRNA vaccines?



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    1 in 10 who develop blood clots will die according to his post quoted from the HSE site, if 1 in 300,000 develop blood clots and 1 in 10 of those die, it's reasonable to conclude that @random.stranger is concerned about actual death from blood clots caused by a vaccine.

    Lunacy to be concerned about that, eh?



  • Posts: 0 [Deleted User]


    I am sure they have evidence the mRNA vaccines are more dangerous and it’s not just a misinformed rant from an inflated sense of their own knowledge



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Conversely I'm sure you have the evidence that Covid-19 mRNA vaccines are overall exceptionally safe, not just in the now, but well - well into the future. Or are you going on a hope cast based on an inflated sense of your own knowledge?



  • Posts: 0 [Deleted User]


    I am sure you will be able to establish a mechanism by which the vaccine will continue to have an effect long after they have left the body.

    Over 12 months now in clinical trial patients and nothing other that immediate effects being shown

    Have a read




  • Registered Users, Registered Users 2 Posts: 4,998 ✭✭✭fly_agaric


    Got my Janssen jab a few hours behind you, should we be feeling guilty for being self entitled ##*!s who took vaccines that would probably have otherwise been binned, while people argue against using these vaccines to avoid waste?

    I didn't really get Danno's point (about rule bending) in his response to me there either. It is (or was - if government/HSE are not going to bother administering it any more??) an available, approved vaccine. I thought it is there to be taken?

    Now if everyone wanted to choose that one and would accept nothing else, there's a problem. Afaik the EU ordered enough of it for the whole population but the company has failed to produce anything like that amount. Ireland has only administered 231k doses according to Covid Tracker App vs 4.7m doses of Pfizer/Biontech vaccine.

    Post edited by fly_agaric on


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  • Registered Users Posts: 4,450 ✭✭✭McGiver


    Immune/immunological reaction to injected lipid nanoparticles, could be one mechanism. We've never had these injected en masse before.

    But a protein-mediated immune reaction is also possible. As you know almost all allergic reactions are protein-mediated.

    The famous narcolepsy association with GSK H1N1 flu vaccine seems to be protein mediated as well (specifically immune protein).

    Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2 | Science Translational Medicine (sciencemag.org)

    Or likely involved a reaction to both vaccine and the wild virus:

    After searching for a mechanism for 8 years, the only plausible hypothesis seems an interaction between H1N1 wildtype virus infection and the administration of an adjuvanted vaccine.

    Re: Pandemrix vaccine: why was the public not told of early warning signs? | The BMJ

    There is zero evidence that spike protein translated from the mRNA cannot cause allergic reactions or start some sort of a negative pathway down the line e.g. in combination with the wild virus. Yes, currently there is no evidence, but absence of an evidence of a negative effect doesn't equal absence of a negative effect. Pharmacovigilance takes a while and unexpected events happen.

    We will need more time and data from the global Phase IV trials which are currently ongoing on all 1 billion of us who had got mRNA vaccines.



  • Registered Users, Registered Users 2 Posts: 442 ✭✭random.stranger


    The HSE never opened it up to the 35-49 cohort, but it looks like they are now quietly removing it from circulation.

    Here is an article Wibbs & Danno have both linked to earlier in this thread:


    https://www.irishtimes.com/news/health/pharmacists-in-vaccination-centres-warn-of-doses-going-to-waste-1.4652314


    I don't understand why we have posters on this thread so enthusiastically opposing giving people the option to use these vaccines, rather than letting them go to waste.



  • Registered Users, Registered Users 2 Posts: 442 ✭✭random.stranger


    I just want to thank you for quoting that post before the edit @Danno :)


    I don't have evidence that mRNA vaccines are more dangerous & never suggested they were. We are living in uncertain times, working with vaccines which haven't been fully tested, but have been allowed under emergency authorisation. I have a fundamental mistrust of anybody that can tell me with certainty that a particular vaccine is 100% safe, if that was the case there would be no need to sign a disclaimer. Credible scientists tend to deal with probability rather than certainty. That National Geographic article builds on a history of other vaccines, none of which are mRNA based.


    I don't feel comfortable using an mRNA vaccine, I feel much more comfortable taking a vaccine which uses an older technology that has been used on the public over extended periods of time. I don't think anybody will really know what the best option is until years to come & we have the benefit of hindsight (but hey, that's just a misinformed rant from an inflated sense of my own knowledge).



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    It's not enthusiasm, it is reluctant acceptance. In a system administering upwards of 300K a week at its peak some waste was inevitable. One would not expect a process of this size to be flexible enough to adjust for very small numbers of a vaccine whose cycle had finished.



  • Registered Users, Registered Users 2 Posts: 442 ✭✭random.stranger


    I wouldn't have got a vaccine only for coming across this thread, there are other people in the same boat who weren't so lucky. I think it's poor form by the government, Janssen is one of the easiest vaccines to store, saying they couldn't distribute them is the equivalent to saying they couldn't deliver milk to a few shops around the country. They have made a conscious choice to not count the vaccines, to quote the Irish Times article "Sources working in the vaccination centres who spoke to The Irish Times said that in some centres there are vials which could provide more than 2,500 jabs if they were used.", if that's in some centres, I dread to think what the total figure is.

    In the best case for government each of those doses will be replaced by an mRNA dose & not available for other less fortunate countries, in the worst case, each of those doses could potentially vaccinate a person who would otherwise refuse a vaccine. This is a failure of government in my opinion & a victory for the anti-vaxxers.



  • Posts: 0 [Deleted User]


    So no long term mechanism then.

    And phase IV, for any drug, is post market surveillance



  • Registered Users Posts: 7,237 ✭✭✭mcmoustache


    Homeopathically, it could remain in the body forever, getting stronger with every píss.



  • Registered Users Posts: 620 ✭✭✭aidoh


    Has anyone had any luck in finding somewhere that still administers J&J or AZ vaccines?

    I don't want to take an mRNA vaccine but don't seem to have another option now.

    I also don't want to get into a discussion at all about why I'm hesitant to take an mRNA vaccine - just very interested in leaning into the experience of posters in this thread to see if anyone has successfully sought a J&J or AZ shot recently and, if so, how?

    Cheers.



  • Registered Users Posts: 784 ✭✭✭daydorunrun


    I was registered with 6 or 7 pharmacy's and never heard a thing. Like you I wanted to get vaccinated but didn't want the mRNA- It's the only show in town now though it seems.

    “You tried your best and you failed miserably. The lesson is, never try.” Homer.



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  • Registered Users Posts: 784 ✭✭✭daydorunrun


    Just got appointment for J&J in Nutgrove on Thursday thanks to the advise from another poster (hadn't checked around for a while because I thought the J&J ship had sailed) - will report back if they allow me receive it seeing I'm one of that weird 35-49 yr old cohort!

    “You tried your best and you failed miserably. The lesson is, never try.” Homer.



  • Registered Users Posts: 15 Vic987


    So you encouraged your child to take an vaccine that they didn't need and which is under conditional marketing, uses an experimental technology and has no medium or long term data on safety/efficacy to protect others. You're some hero!



  • Registered Users Posts: 15 Vic987


    For anybody who ever wondered why the Church held so much power in Ireland for so long I think recent events have shown how that happened. We Irish revel in being best in class and need to be part of the herd. An added bonus is having reprobates to look down on. I loved the glee earlier in the summer when my age cohort were being vaccinated and all were delighted to virtue signal by sharing their medical details.

    But, instead of going to hell, sinners like myself are going to ICU to take a real sick person's bed or else planning to kill our grannies.



  • Registered Users Posts: 620 ✭✭✭aidoh


    I managed to get an appointment sorted for this Friday by cold-calling a few pharmacies in my area.

    All of them bar one weren't doing viral vectors anymore.

    If anyone's in the same boat as me, pick up the phone and chance your arm.



  • Registered Users Posts: 784 ✭✭✭daydorunrun


    Got J&J vaccine today in Boots, Nutgrove. Steady steam of people getting it. Not much stock left I was told- really only getting it to help the overall percentage in order to allow the country open up fully.

    “You tried your best and you failed miserably. The lesson is, never try.” Homer.



  • Registered Users, Registered Users 2 Posts: 19,077 ✭✭✭✭Bass Reeves


    Ah that great we will have a medal ceremony for you Sunday morning at 6.30am at the back gate if Croke Park

    Slava Ukrainii



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  • Registered Users Posts: 784 ✭✭✭daydorunrun


    Why the snide attitude? Everybody has taken the vaccine for there own reasons, fear of getting sick, vulnerable relatives or the reason I gave- getting the overall vaccination numbers as high as possible before opening up. I was being called selfish for not taking the first vaccine I was offered and now I'm some kind of glory hunter for stating my reasoning for seeking out and taking this one 🙄

    “You tried your best and you failed miserably. The lesson is, never try.” Homer.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Just like the bishops of old, smug and arrogant.



  • Registered Users Posts: 328 ✭✭scouserstation


    I see this was approved today, hopefully will be available here soon as due a booster and would prefer taking this to the pfizer or moderna vaccines



  • Registered Users Posts: 336 ✭✭NaFirinne


    If vaccines were going to lead the country to re-open. It would have been re-opened already.



  • Registered Users Posts: 343 ✭✭Shilock


    is this a more traditional vaccine than the mRNA, as I've few vaccine hesitant friends who are waiting for something other than mRNA gene therapy. I took the gene therapy, in a way I wish I hadn't and held out for a live attenuated vaccine. I just have a feeling I made the wrong choice. The live attenuated vaccines are around for years, there's no telling about the long term impact of the mRNA gene therapy.



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  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    I can’t comment on your choice of vaccine, but to answer your question, yes this is different, closer to a “traditional” type although not exactly the same. More here: https://www.theguardian.com/world/2021/dec/20/approval-new-covid-jab-germany-unvaccinated-novavax-nuvaxovid

    This is good news for those who can’t take mRNA for medical reasons. the fact the govt isn’t providing an alternative to those people is scandalous.

    There will always be those who choose not to get it. Their choice, IMO.

    And speaking of choice, more choice in vaccines is a good thing, it reduces mistrust in the system. There’s a fair few people I’ve met who are questioning if Pfizer are running our country now since that’s all we seem to have on order (while we use remaining stock of Moderna). More variety means people feel more in control of their choices. The less reason to make up conspiracy theories, the better.



  • Moderators, Science, Health & Environment Moderators, Society & Culture Moderators Posts: 60,173 Mod ✭✭✭✭Wibbs


    Just a point. the mRNA vaccines are not gene therapy. They don't change the DNA in your cell, which is what gene therapy would do. They are a gene based therapy, that instructs your immune cells to make antibodies based on the instructions in the vaccine. Quite a different thing. I personally chose to avoid the mRNA based vaccines because of the history of that medical tech and rushed into service timeline and instead chose the viral vector type, but not because the mRNA vaccines are "gene therapy".

    I very much agree with this. Again personally speaking, would I take a booster of J&J? Yep, no problem, jab me up. I won't take a Pfizer and especially not a Moderna booster. And I doubt I'm alone in this. Actually I know three vaccinated people who feel the same. I would have no issue with paying for my booster either.

    Rejoice in the awareness of feeling stupid, for that’s how you end up learning new things. If you’re not aware you’re stupid, you probably are.



  • Registered Users, Registered Users 2 Posts: 6,330 ✭✭✭Former Former Former


    This is good news for those who can’t take mRNA for medical reasons. the fact the govt isn’t providing an alternative to those people is scandalous.

    Genuine question, who cannot take mRNA vaccines for medical reasons? I'm not aware of any significant exclusions?



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    What are your thoughts on getting Novavax as a booster to compliment your J&J in the following situations:

    • Hold off getting a booster until we had J&J stock back even if Novavax was available
    • Hold off getting a booster until we had Novavax stock in even if J&J was available
    • Take the first booster that came along - either J&J or Novavax

    Would it bother you to mix and match? If not - would you take AZ or any others (excluding mRNA's)?

    Just interested in people's thoughts on this.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    There are a few out there that develop reactions to the ingredients used in the mRNA shots.

    Similarly - people can develop reactions to the ingredients used in J&J and AZ.



  • Registered Users Posts: 343 ✭✭Shilock


    Thanks for letting me know how these vaccines work, sometimes I get confused with all the different emotionally charged opinions and comments. You're able to simplify it in lay terms.

    Thanks for clearing that and explaining in a way a jack of all trades and master of none guy like myself can absorb it, and it makes sense.

    20 Euro for a booster is a drop in the ocean and it's good to have a choice in what you want rather than being told what you need.



  • Registered Users Posts: 1,975 ✭✭✭PeadarCo


    The thing is the vaccines haven't been rushed. They just have a huge amount of money thrown at them. A good comparison is the moon landing in the 1960s/70s compared to the present day US moon programme. The US went from 0 space flight experience to moon landing in less than 10 years. Where as today the current Artimes programme has dragged on for years despite far better technology and experience of space flight in general. The big difference is money. The Apollo programme received far far more money than the current programme.

    In the case of Pfizer they could run certain sections of the trials concurrently because of the financial incentive. It's not unusual for drugs to fail during testing and each trial costs money. For most drugs its not worth it financially to run trials concurrently due to the costs of failure.

    MRNA vaccines and technology behind it has been researched for 50 odd years so It's not new or unheard of. The Covid virus is RNA. So again it's not something that's new to science even if the specific virus is. Also the current vaccines are some of the most tested ever. We have hundreds of millions of doses administered at this stage and scientists and health care professionals worldwide are reviewing the real world impact of the Pfizer and Moderna vaccines. Unless you think all these thousands of different people are all collectively lying about the side effects of the vaccine. We know the side effects of the Pfizer and Moderna vaccines and we know the side effects of Covid. Its obvious which has the more risky long term side effects.



  • Registered Users, Registered Users 2 Posts: 6,330 ✭✭✭Former Former Former


    Well yeah, you will always get hypersensitivity reactions but the numbers would be absolutely tiny. That's nothing to do with the mRNA.



  • Moderators, Science, Health & Environment Moderators, Society & Culture Moderators Posts: 60,173 Mod ✭✭✭✭Wibbs


    I'd prefer a second J&J. There have been studies done on that, so it's a known thing. Novavax wouldn't be.

    That said I can see boosters becoming somewhat moot for the general population because of the spread of omricon. As it stands currently I don't know anybody in my circle who doesn't know someone who has had it, or has it themselves. It seems to be everywhere. I've certainly been exposed to it twice in the last week. No symptoms, but am awaiting a test result. I'd be surprised if I didn't get a positive. All who have had it report either a couple of days feeling meh/slight headcold, or postive but asymptomatic. That includes two unvaccinated types, both had two to three day headcolds with added fatigue on one of the days. All those positives are "boosted" now for at least six months.

    Rejoice in the awareness of feeling stupid, for that’s how you end up learning new things. If you’re not aware you’re stupid, you probably are.



  • Registered Users, Registered Users 2 Posts: 69,732 ✭✭✭✭L1011


    There's also studies showing that J&J, even boosted, has exceptionally poor response to Omicron. It'd be approaching pointless.



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