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The Ivermectin discussion

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Comments

  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    You'd think that would be definitive, yet it turns out that almost every study on that list has issues, it's 30 tweets long, so grab a cup of tea.




  • Posts: 0 [Deleted User]


    Personally I would trust over 30 peer reviewed studies over someones tweets refuting them especially someone who has "trust me" written on their t-shirt.



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    And just digging in a little bit to the website hosting the studies itself and it looks like there's a whole web of misinformation and crackpot remedies behind it.



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    I think that's a big part of the problem, it looks slick and the data looks believable (especially if that's already the narrative you're following), but it all falls apart at the slightest scrutiny, you can't polish a turd.

    Baricitinib study looks interesting, it's a hospital treatment post infection rather than prophylaxis (uses used for arthritis and can weaken the immune system).



  • Registered Users, Registered Users 2 Posts: 382 ✭✭Unicorn Milk Latte


    This Twitter feed is a perfect example of what I mentioned earlier - 'flooding the zone with sh*t' as a disinformation tactic.

    The Twitter feed brings up lots of alleged Covid treatments in quick order: Aspirin, Niclosamide, Melatonin, Ivermectin, Vitamin D, Hydroxychloroquine, Zinc, along with claims that masks are useless, paranoia about information suppression (while posting this very 'information' on flipping Twitter..), all your familiar conspiracy BS.


    It also mentions scientific studies, to give itself an air of legitimacy and competence, while deliberately misrepresenting the content of the same studies.



  • Posts: 0 [Deleted User]


    Good to know that you can see that these peer reviewed studies only look believable but really fall apart under scrutiny by you.

    Personally I will go with what the professionals think. The professionals whose job it is to peer review studies. The professionals who peer reviewed these studies and seen that they do not fall apart under scrutiny by professionals.



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    a) That website is part of a disinformation ring of various treatments and conspiracies, no professionals involved

    b) The person who was checking all the studies is an epidemiologist, which is exactly the type of professional you want to review those studies

    But sure, if you want to go ahead and analyse and show where it's wrong, be our guest.



  • Posts: 0 [Deleted User]


    a) I was not talking about the website. I was talking about 39 peer reviewed studies and yes the people who peer reviewed these studies are professionals. These are the professionals I would trust over you.

    b) Yes an epidemiologist tweeting his analysis with 'trust me' written on his t-shirt. A professional checking these studies would not be doing it by tweeting. It would be like having the studies peer reviewed and then tweeted rather than published in medical journals.


    I do not have the ability to analyse the studies. But the professionals who peer reviewed them do. I'll go with the professionals on this one



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    You've lost me, most of the studies linked aren't full trials or aren't proclaiming the efficacy of Invermectin, the person who collated them took small parts of data from each one to try and support the narrative they're trying to push, I doubt the authors know they're being used this way.



  • Posts: 0 [Deleted User]


    You can claim to be lost and then analyse these studies yourself and come to these conclusions.

    Again I will go with the professionals who have analysed these studies and go with their conclusions.

    https://journals.lww.com/americantherapeutics/Fulltext/2021/08000/Ivermectin_for_Prevention_and_Treatment_of.7.aspx




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  • Posts: 0 [Deleted User]




  • Registered Users, Registered Users 2 Posts: 8,570 ✭✭✭ceadaoin.


    Also meanwhile...someone is lying and it seems rolling stone is spreading misinformation. I'm sure this correction will gain widespread coverage, right?


    Although Dr. Jason McElyea is not an employee of NHS Sequoyah, he is affiliated with a medical staffing group that provides coverage for our emergency room.

    With that said, Dr. McElyea has not worked at our Sallisaw location in over 2 months.

    NHS Sequoyah has not treated any patients due to complications related to taking ivermectin. This includes not treating any patients for ivermectin overdose.

    All patients who have visited our emergency room have received medical attention as appropriate. Our hospital has not had to turn away any patients seeking emergency care.

    We want to reassure our community that our staff is working hard to provide quality healthcare to all patients. We appreciate the opportunity to clarify this issue and as always, we value our community’s support.


    https://nhssequoyah.com/



  • Registered Users, Registered Users 2 Posts: 7,321 ✭✭✭circadian


    I don't understand why people are actively dismissing the advice of medical professionals. Like, why are you going out of your way to find any evidence, no matter how ropey, to use to dismiss people who's entire career is built on studying and advising on this kind of thing?



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    Without the requisite regulatory approval there is a very strong risk of quackery and these people need to go from claiming to proving. More papers, interviews, YouTube videos or just shouting will not do that.



  • Registered Users, Registered Users 2 Posts: 7,260 ✭✭✭Former Former Former


    The guy who invented the "MMR vaccine causes autism" lie was a medical doctor. Too many people were blinded by that to see through it.

    If what they're saying doesn't make sense and isn't backed up by evidence, then it doesn't matter what their qualifications are.

    There is no reliable evidence that ivermectin works in Covid. What we're seeing now is more and more claims being made on the back of bad science and anecdotal evidence, we have yet to see a well designed study prove any effect.

    The doctors pushing it are hopelessly compromised. The most vocal, Pierre Kory, is a full blown conspiracy theorist and absolute crank.

    Post edited by Former Former Former on


  • Registered Users, Registered Users 2 Posts: 382 ✭✭Unicorn Milk Latte


    One key goal of creating all this noise and the paranoia talk of suppressed information is to distract from obvious, common sense questions.


    When you use Ivermectin as a dewormer, the chemical mechanisms that make it effective as a dewormer are known in detail, and well documented.

    When it comes to the use of Ivermectin as an antiviral for SARS-COV-2, there are not even basic ideas of how it is supposed to work on a chemical level, much less any studies that provide detail of the exact mechanisms.



  • Registered Users, Registered Users 2 Posts: 217 ✭✭ohnohedidnt



    Ivermectin has since been confirmed to inhibit IN nuclear import and HIV-1 replication (Wagstaff et al., 2012). Other actions of ivermectin have been reported (Mastrangelo et al., 2012), but ivermectin has been shown to inhibit nuclear import of host (eg. (Kosyna et al., 2015van der Watt et al., 2016)) and viral proteins, including simian virus SV40 large tumour antigen (T-ag) and dengue virus (DENV) non-structural protein 5 (Wagstaff et al., 2012Wagstaff et al., 2011). Importantly, it has been demonstrated to limit infection by RNA viruses such as DENV 1-4 (Tay et al., 2013), West Nile Virus (Yang et al., 2020), Venezuelan equine encephalitis virus (VEEV) (Lundberg et al., 2013) and influenza (Gotz et al., 2016)



  • Registered Users, Registered Users 2 Posts: 382 ✭✭Unicorn Milk Latte


    Like I said, lots and lots of noise, to distract from asking basic questions of how it is supposed to be effective with SARS-COV-2.


    Bringing up effectiveness for a fundamentally different virus that is transmitted via insect bites is not relevant - except when the goal is to create a distraction.


    The fact that all of your links are not leading to the studies you mention, but to just one that describes - as brought up 100 times before - that Ivermectin inhibits SARS-COV-2 viral replication in vitro - when used in doses 100x as high as safe in human use, without explaining the chemical mechanism of how it can work as antiviral in humans, makes my point.



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  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    This is just a list of things Ivermectin is claimed to have some effect on and none of them are COVID. An article I'd missed from March, which makes some salient points, doing proper clinical trials being chief among them.




  • Posts: 0 [Deleted User]


    The most easily quantifiable way to describe the indefensible lack of “approval” for ivermectin in COVID-19 is to note the actual amount of supportive clinical trials evidence in COVID-19, both randomized (31) and observational (32), including more than 26,000 patients with the near majority of all studies finding at least some important benefit with treatment.

    Then compare that evidence to the average amount of evidence relied upon to formulate the treatment guidelines of the Infectious Disease Society of America:

    In a 2010 review of 65 of its most recent guidelines, the IDSA found that 50% of guideline recommendations were made without any trials evidence in support and were termed “expert opinion only.”

    Another 31% of guideline recommendations were based solely on observational studies, while only 16% of all recommendations were based on at least one randomized controlled trial.

    In other words, the number of legitimate clinical trials for ivermectin have been far superior to those for the IDSA’s treatment guidelines.

    Furthermore, ivermectin was approved for the treatment of scabies by the World Health Organization based only on 10 randomized controlled trials, including 852 patients. Despite the fact that these trials found ivermectin inferior to the cream it was being tested against, it still won approval due to its low cost and ease of administration.

    I am no medical expert and will no pretend to be one. But the above and censorship of ivermectin and the disingenuous reporting and statements by the authorities and media by referring to the animal version of ivermectin are all signals to me that ivermectin works



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    When you start a post in such a strident manner you are clearly not open to to any other explanations. For all the claimed studies it is still unproven and has been observed again and again on this thread there are a lot of issues with these studies. Until it produces a large enough trial where it is generally agreed the data seems to show some benefit it will continue to see it as an animal drug.


    And if you believe it works you are free to take it.



  • Posts: 0 [Deleted User]



    Interesting paper here published two days ago addressing the concerns of the BMJ Evidence Based Medicine regarding ivermectin

    https://osf.io/peqcj/



  • Registered Users, Registered Users 2 Posts: 7,260 ✭✭✭Former Former Former


    Edit - forget it



  • Registered Users, Registered Users 2 Posts: 3,480 ✭✭✭xhomelezz


    After reading this, I have to check road traffic signals. Red might be green by now, not even mentioning orange one..



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  • Posts: 0 [Deleted User]


    Well I printed it on paper and it had to be published for me to read it.

    There is no need for new data.

    I have no medical expertise though I was interested in the concerns raised by the BMJ. So I found it interesting as it addressed those concerns whilst making sense to me. Maybe for others too, so I shared it.



  • Posts: 0 [Deleted User]


    I see the Indian government has just revised their list of essential medicines to include ivermectin used in Covid treatment. Another signal that ivermectin works against covid


    Post edited by [Deleted User] on


  • Registered Users, Registered Users 2 Posts: 7,260 ✭✭✭Former Former Former


    That's a price control mechanism.

    They've deleted oral contraceptives from the list. By your logic, that means the pill doesn't work and we will soon be awash with unplanned pregnancies.



  • Registered Users, Registered Users 2 Posts: 217 ✭✭ohnohedidnt


    Covid is an RNA virus, the link beside that is covid specific.

    I'm neither for nor against ivermectin btw, if somebody says drinking petrol helps, I couldn't give a fiddlers, let them try it.

    I think it's a bit disingenuous to suggest there is not even a basic idea of how it would work, a quick googling of the mechanism shows at least a few potential mechanisms. Maybe you're looking for more detailed chemical formulas or something, but if I found that I wouldn't even know what I'm looking at.

    It's a human drug, with known safe human doses, if I had some handy when I get covid, would I take it? Sure. Why wouldn't you? Do you have a mechanism for how it could hurt?

    www.ncbi.nlm.nih.gov/pmc/articles/PMC8203399/



  • Posts: 0 [Deleted User]


    Yes they reduced the price for drugs. They have not deleted oral contraceptives from the list. They delete one specific oral contraceptive (Ormeloxifene). So your point is moot.

    Post edited by [Deleted User] on


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  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool




  • Posts: 0 [Deleted User]




  • Registered Users, Registered Users 2 Posts: 7,260 ✭✭✭Former Former Former


    You're seeing what you want to see here.

    You said that being on this list is proof that ivermectin works.

    Logically then, being taken off this list must mean the opposite, ie that those drugs don't work. Right?

    But they've removed atenolol, which millions of people take for blood pressure. They've removed ethinylestradiol and norethisterone, a common birth control.

    These drugs haven't stopped working, they just don't need to control the price anymore.

    Conversely, this isn't evidence that ivermectin works, it just means that the Indian government doesn't want to be paying through the nose for it.



  • Posts: 0 [Deleted User]


    Ok as you say let’s use logic

    To add a drug to the essential medicines list there can be many reasons, like cost, availability etc. Though one reason that must exist for it to be added is that it at the very least works. Then factors like cost, availability come into play.

    To delete a drug from the essential medicines list you say it must not work. When in fact there are many reasons to delete a drug from the list even though it does work such as a cheaper alternative, more readily available alternative, better results from alternative. in all cases the deleted drug works.

    With your logic the Indian government added ivermectin to its essential medicines list even though it does not work but because it is cheap.



  • Registered Users, Registered Users 2 Posts: 34,957 ✭✭✭✭odyssey06


    It works against parasites - proven.

    People are buying it hoping it works against covid - which in unproven.

    But which pushes up demand.

    To claim its place on the list is proof it works against covid is utterly without foundation from what you have posted so far.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Posts: 0 [Deleted User]


    So you are saying the Indian government have added a drug (Ivermectin for Covid) to their list of essential medicines that does not work?



  • Posts: 0 [Deleted User]


    The problem with this guy is that he has never, and I mean ever, not even one time, in all of the time he's been posted across thousands and thousands of tweets, said anything that deviates from the mainstream narrative of the moment. Not even when that narrative has later been proven wrong. So he's a great source for finding out "what is current mainstream thinking on X Covid thing", but very poor if your question is "what is the validity of mainstream thinking on X Covid thing".



  • Registered Users, Registered Users 2 Posts: 34,957 ✭✭✭✭odyssey06


    Its works as an anti parasitic medicine and has been on the WHO list of essential medicines for this reason - before covid.

    That the Indian government added it to the list is a function of demand, its not necessarily a statement of support for it as a covid treatment.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Posts: 0 [Deleted User]


    The article clearly states ivermectin used in Covid treatment. Are you saying it does not work but because there is high demand the Indian government added it to their list of essential medicines?



  • Registered Users, Registered Users 2 Posts: 34,957 ✭✭✭✭odyssey06


    I dont know if it works against covid as a preventative.

    I am very sceptical it works as a treatment for covid given the failure of the recent 1000+ patient McMaster trial in Brazil.

    It is a proven anti parasitic medicine and on the WHO list for that reason.

    I see no evidence its presence on Indias list is for any reason other thsn demand.

    The article you link is not evidence - scan the list for Ivermectin and it's listed as an anti parasitic med.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



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  • Registered Users, Registered Users 2 Posts: 1,218 ✭✭✭snowcat


    Ah cool So if your diet is good you have little to fear from Covid. If not and your diet is **** take quercetin vit d vit c zinc and you will be fine.



  • Posts: 0 [Deleted User]


    The article clearly states ivermectin used in Covid treatment. The fact that it is also referred to as an anti parasitic is true, because it is. You say you see no evidence for Ivermectin being added to the Indian list of essential medicines for any reason other than demand. I find it hard to believe the Indian government added ivermectin to its list of essential medicines because of demand only. If true they have a lot to answer for.



  • Registered Users, Registered Users 2 Posts: 34,957 ✭✭✭✭odyssey06


    The article lists the essential medicines added and I have copied and pasted this from the article.

    "Ivermectin (anti-parasitic)"

    Its has been on the WHO list of essential meds for years before Covid for that reason. Seems important to ensure in India it is still available for that proven purpose.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    No, get a vaccine and there's a very high chance you'll be fine.

    Also, live healthily, just because.



  • Posts: 17,378 ✭✭✭✭ [Deleted User]


    Last I read, 88% of Irish adults are fully vaccinated. Who exactly are you preaching to here? The final 12%? Do you think Ivermectin is stopping Irish people getting vaccinated?

    Feels to me like a lot of people import not only social issues but also statistics. Like some partisan battle is happening on their doorstep. There'll be a thread on here calling for Irish Walmart to stop selling guns soon.



  • Posts: 17,378 ✭✭✭✭ [Deleted User]


    The more I think about this, the less I get it. Like if a loved one is dying in the hospital, you try everything.

    Until it's absolutely 100% proven to do absolutely nothing, why such an extreme reaction to in a country with no problems with vaccine uptake? I can't imagine telling someone to not take horse medicine, them dying, and it coming out later that it increases chance of survival even a little bit.

    Like it doesn't even seem to be an either or. You can take it and if it works, it works. People take medicine with terrible side effects all the time hoping it will save them, and does Ivermectin even have those?

    Would people here really mock someone in hospital for taking it?



  • Registered Users, Registered Users 2 Posts: 17,324 ✭✭✭✭astrofool


    That's not how medicine works, every treatment isn't thrown at a patient just because 1 might work, similarly, if an unapproved medicine is used and there's a bad side effect the hospital and doctors are then liable for damages. Otherwise, we'd be using all the phase 2 medicines that look promising against Covid-19 rather than waiting for approval, some look very promising and are passing properly run trials.

    Invermectin only comes up because it's already approved for parasite infection using a few doses, to treat Covid-19, the dosage and efficacy needs to be worked out via trials and if efficacious, go for approval.

    Then you have the difference of using it as a prophylaxis vs. a treatment and on top of that, most of the self administers are usually in non-vulnerable groups anyway which skews the success data.

    Is Israel using it? They're usually not shy in ploughing ahead with something if it might work.



  • Registered Users, Registered Users 2 Posts: 6,280 ✭✭✭Wolf359f


    "Further validation may be required to confirm a direct, causal link between diet and COVID-19 illness severity"

    You could probably do a survey that smart phone users are less likely to end up with severe illness, or Xbox & PS users or people who vape... basically when you take a trend that mainly favors young people you will see a less likely severe covid outcome. Did you know that people who witnessed the moon landings are more prone to severe covid outcome than those who witnessed 9/11?



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  • Posts: 0 [Deleted User]


    Theres a bit more to it than that.

    I listened to some doctors recently who said avoid meat when you have covid infection for 2 weeks to reduce inflammation.

    We eat too much meat in the west.



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