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The Ivermectin discussion

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  • Registered Users Posts: 1,937 ✭✭✭PeadarCo


    When it comes into people not taking vaccines its a distrust of good science. Spreading bad science or absolute snake oil is a massive problem and a driver of people not taking vaccines. Even on this thread we have people who distrust pharma companies. That's fair enough a healthy amount of skepticism is always warranted about anything. However the pharmaceutical industry is one of the most regulated industries out there. Snake oil sales people are not subject/don't adhere to the same regulations. If you are going to be skeptical of the pharmaceutical industry fair enough but you should be even more skeptical of alternative medicine and claims that are unsupported by science.

    Muddying the water with bad science and suggesting doubt where there is none is a trade mark tactic of science deniers. That's my issue about your post about Invecterim. There is no good science behind it when it comes to the treatment of Covid based on my reading of the thread. You post constantly suggesting otherwise which creates doubt to people of certain disposition. If you look at the whole MMR debacle and even the thread on this forum about vaccine effectiveness. It's the same strategy constantly reference bad science to create doubt where there is none. Inevitably some people will listen won't get a vaccine and die.

    As others have said there is a massive difference between raising awareness of potential new treatments and constantly pushing unproven treatments.

    Post edited by PeadarCo on


  • Registered Users Posts: 172 ✭✭PureIsle


    Yeah, sure.

    That is why in hospitals Covid patients are injected with a massive dose of Vit D.

    No, I won't be searching for you to confirm that.

    Believe what you like, I am not here to convince you of anything.



  • Posts: 0 [Deleted User]


    Whether or not you feel you want to convince anyone of anything - or not - the simple fact is that if you say something and pre-decline any attempts at verification - then it is difficult to treat your words as anything but stuff you made up on the spot.

    That said however - whether or not a particular procedure or medication is used in practice in hospitals - is not in and of itself evidence of efficacy or veracity. Especially in places like the US. And you are not clear above whether you are referring to practices in Ireland - another country - or universally in all hospitals everywhere.

    But just to give you a random example of what I mean. The British Medical Journal sifted through thousands of standard medical treatments (Source Paper Titled: Evidence at the point of care - see some of us do not just state things and refuse to look up the citations for our own positions). Evidence for the benefit of the standards was only found in barely 40% of them.

    Half of them had entirely unknown effectiveness. Yet Medical Insurance was paying for them and doctors were using them.

    So if you want to know if a treatment or procedure is effective or useful - it being a routinely given treatment is simply misleading and irrelevant in many cases. We should never ask "What are hospitals doing" so much as "Why is the hospital doing that?".



  • Registered Users Posts: 2,010 ✭✭✭GooglePlus


    It's well proven now that Vitamin D plays a vital role in our immune system and a number of other functions within the body. If you're chronically low on Vitamin D throughout your life, you might not even notice but you're massively increasing your risk of premature death by Cancer and other age related diseases.



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  • Registered Users Posts: 849 ✭✭✭MilkyToast


    As far as I'm aware there is no established causal link between vitamin D deficiency and more severe Covid-19, but there is correlation. Honestly, that is enough for me, in a pandemic situation. Where the suggested therapy is abundantly available, provably safe and has enough correlation with better outcomes, it should be provided to patients who want to use it on the basis of informed consent. I've been taking high-dose vitamin D since a while before the pandemic, anyway.

    “Of all tyrannies, a tyranny sincerely exercised for the good of its victims may be the most oppressive. It would be better to live under robber barons than under omnipotent moral busybodies. The robber baron's cruelty may sometimes sleep, his cupidity may at some point be satiated; but those who torment us for our own good will torment us without end for they do so with the approval of their own conscience." ~C.S. Lewis



  • Posts: 0 [Deleted User]


    Diet and vitamin d levels are important for optimum health.

    This is an inflammatory disease, would it therefore be wise to have an anti-inflammatory diet with adequate vitamin d levels?



  • Posts: 0 [Deleted User]


    Zoe research study that involves millions of britons found correlation in reduced liklihood of people of testing positive who took the following:

    Multivitamin.

    Vitamin D.

    Probiotic (improves immune system/gut health).

    Omega 3.

    No correlation with people who take vitamin c as a preventative, vitamin c seems more useful when you are sick.



  • Registered Users Posts: 849 ✭✭✭MilkyToast


    I don't know what point you're trying to make? I said there's evidence of correlation and you made two posts saying there's evidence of correlation. Where's the disagreement?

    “Of all tyrannies, a tyranny sincerely exercised for the good of its victims may be the most oppressive. It would be better to live under robber barons than under omnipotent moral busybodies. The robber baron's cruelty may sometimes sleep, his cupidity may at some point be satiated; but those who torment us for our own good will torment us without end for they do so with the approval of their own conscience." ~C.S. Lewis



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  • Posts: 0 [Deleted User]




  • Registered Users Posts: 13,751 ✭✭✭✭Goldengirl


    This is true . Not 'massively 'but in part .

    The issue here is people grasping on to very much trace supplements and crediting them with way more effects than has ever been attributed except in quackology .

    Most doctors would check Vit D on their patients routine bloods and recommend a supplement in patients who are at risk or elderly . Other younger patients would be told to eat more green veg or get out and get a bit of sun .

    The real benefit of Vit D is in preventing infection by building immunity .

    It doesn't have any role in treatment .

    @Woody79 An anti inflammatory diet , like the Mediterranean diet while a good thing , is for chronic inflammatory conditions.

    What happens in Covid is an acute reaction and in most cases that is what is needed to clear and fight off the virus . That is why anti inflammatory drugs like steroids are kept until strictly necessary to treat because doctors don't want to dampen your body's natural response , initially anyway . The problem is when the body's response goes into overdrive , the cytokine storm, and attacks itself . That is when multiple organ inflammation and damage occurs .

    Diet may help after an infection alright .

    Sorry not meaning to be negative but it's a bxxch of an illness .



  • Posts: 0 [Deleted User]


    Thing is most diets most of the time have perfectly adequate Vitamin D levels already.

    As for diets sure - it's very important I think in general but is also very individual at times - and I tried out many fad and recommended diets myself before I found the one that worked for me. Which meant I read through heaps of absolute bollox nonsense too. I tried read everything and tried much - reading about madness like the Cayenne Pepper diets - and also trying out things like high fat low carb - and then high carb low fat - and vegetarian diets - and total high meat and protein diets - the works. In the end I found a diet where actually eating more has me healthier and fitter and I have not been sick with even a mild cold for quite a few years now.

    People pointing out that "If you're chronically low on Vitamin D" you will have problems are not actually saying anything useful. They are certainly not saying anything that justifies supplementation or with hitting Covid Patients with one off massive doses in the hospital. All they are doing is saying something that is A) obvious and B) applies to just about every other vitamin, mineral, or substance in your diet too.

    A case in point: If you were "chronically low" on arsenic you might even suffer badly. But the fact is A) You are unlikely to ever be chronically low on it and B) the fact that being chronically low on it would be a bad thing is not relevant when considering whether you should be taking supplements of it when in fact supplementing would be harmful.

    Vitamin D is essentially the same thing! You are A) unlikely to be low in it and B) supplementing is unlikely to do most people any good and might in fact be harmful.

    Further those people who are "chronically low" should not assume that supplementing will even help. It would entirely depend on the cause of their being low. Some causes lend themselves to supplementation while others do not. You need the opinions of doctors to help here. For example if the water level in my bucket is seriously low - and this is because the bottom of the bucket is riddled with large holes - then simply throwing in more water is not going to solve the issue. Treating the symptom and not the cause is often not helpful and sometimes is the opposite of helpful.

    I have never been sure why Vitamin D attracts the particular emotional response it does. Some people are really emotionally invested in it in my anecdotal experience. But when you go to the research there is not much there showing that anything but a very small cohort of people need to have it in their consciousness at all any more than they should be worrying about their arsenic levels.

    But as I think someone already pointed out on the thread in recent days - people do love a pill. It makes some even feel like they are taking control of their health and doing something. Which often feels odd when you see obviously obese people shove in the fast food and then popping vitamin pills because they think it keeps them "fit and healthy". If it works for them great - but one can also wonder if maybe they should try a walk and stop food fisting their gobs sometime :)

    But Covid terrifies some people. So if taking vitamin D pills brings them well being and makes them feel shielded then that is not a bad thing I guess. Placebo effects might even boost not just their well being but some of their health too. Supplementing Vitamin D can actually be harmful though but sure in places like the US one can not even be sure that when you buy a Vitamin D tablet - that it actually contains any Vitamin D. It is so unregulated that some studies of over the counter supplementation there has found that the supplements contain little to no traces of the thing the container purports to be supplementing.



  • Registered Users Posts: 6,224 ✭✭✭Ubbquittious


    I reckon people see "For equine use only" on the packet and then they think "Oh right, that means we can just horse it in"



  • Moderators, Category Moderators, Social & Fun Moderators, Society & Culture Moderators Posts: 23,637 CMod ✭✭✭✭Ten of Swords


    Thread title updated, long overdue



  • Registered Users Posts: 172 ✭✭PureIsle


    Most have heard of the placebo effect and acknowledge it is real. So a substance which should not, technically, have any beneficial effect actually does, because the patient believes it will.

    In IVM we have a substance which is believed to be very beneficial in the treatment of Sars2 infections and the resulting Covid disease. That belief is held by very many people, including some of the very best qualified people in the field as well as many medical personnel.

    IVM has been shown over the very many years of its use for other purposes to be very safe in recommended dosage .... dependent on weight of patient for the most part I believe.

    So, is there any reason NOT to take IVM? ..... none that I know about. In the recommended dosage it has no safety concerns of note, and minimal adverse effects.

    Does it matter to the patient if the effect of taking the substance is due to its inherent properties or to a placebo effect? If there is a beneficial result I certainly would not care, would you?

    It is difficult for me to understand the huge opposition to anyone taking this, or indeed to it being made available on prescription, for whatever reason a doctor prescribes it.

    The medication available to any patient should be between the doctor and the patient, and not dictated by idiots referring to 'horse paste' when they are well aware of it use in humans. After all most of us posting here are not horses ...... but some might well be asses for all I know!



  • Registered Users Posts: 30,582 ✭✭✭✭odyssey06


    Then dont even give them ivermectin, give them a blue pill placebo.

    The recommended dose for ivermectin for parasites is a single dose. Its not meant for or been properly tested for continuous use.

    All meds have side effects its completely irresponsible to advocate widespread use as a placebo.

    If you think you have parasites talk to your doctor about ivermectin.

    If you are concerned re covid take the vaccine - and remember some people are jumping on ivermectin as an alternative to vaccines.

    If you need covid treatment there are proven steroids such as dexamethasone. For home treatment the UK are using an inhaler steroid becotide I think. Not sure of its status here but thats what you should ask your doctor about.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users Posts: 172 ✭✭PureIsle


    An update on the legal case started in India initially against a representative of the WHO for discouraging the use of Ivermectin against Covid, based on the view of Merck a pharma company, and not on any scientific study to back her views. It has moved on since and this is covered in this interview.


    https://www.youtube.com/watch?v=eD9BYCYwsUI



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  • Registered Users Posts: 8,296 ✭✭✭ceadaoin.


    At least for river blindness the protocol is one dose every 6 months for 10-15 years. It's not just a once off but yeah not the same as taking it every day though





  • Registered Users Posts: 1,937 ✭✭✭PeadarCo


    https://www.irishtimes.com/news/health/one-person-hospitalised-after-taking-ivermectin-for-covid-19-in-ireland-1.4680059?mode=sample&auth-failed=1&pw-origin=https%3A%2F%2Fwww.irishtimes.com%2Fnews%2Fhealth%2Fone-person-hospitalised-after-taking-ivermectin-for-covid-19-in-ireland-1.4680059


    One person hospitalised in Ireland as a result of taking Invecterim. Aside from that the most important part of the article is that there currently no plans to apply to use Invecterim as a Covid treatment in the EU which should tell you all you need to know about how effective it is as a treatment for Covid.



  • Registered Users Posts: 172 ✭✭PureIsle


    Lets see if I get this right ..... you say that

    'because there are no plans to use a medication proves it is ineffective as a treatment for Covid?'

    You really need to work on your logic if that is the case.

    I have no definite view on whether it is effective or not, but absence of a plan does not prove it one way or the other.

    I would take it if it was available at least until it was proved ineffective. At this time there is insufficient proof either way, although the majority of published data indicates it is probably effective.



  • Registered Users Posts: 31,085 ✭✭✭✭Lumen


    @PureIsle wrote

    I would take it if it was available at least until it was proved ineffective.

    And therein lies the madness.



  • Registered Users Posts: 1,937 ✭✭✭PeadarCo


    For all practical purposes Invecterim is ineffective for treating Covid. That's the fact. Maybe a some point in the future it may be found to be effective when it comes to Covid treatment but you can say that about anything.

    There is no doubt at the moment. If Invecterim was proven to be effective at treating Covid the people who make it(and will make money off selling it) they would apply for it be to approved for treating Covid.

    All your post is the standard conspiracy theory/science denial which is dangerous. Based on this thread the evidence does not suggest its effective. Any of the studies that been put forward to show otherwise have various problems with their methodologies. The evidence on this thread is backed up by the stance of the manufacturers of the drug in question. At the moment in Ireland Invecterim when it comes to treating Covid is as effective as snake oil. It's not approved and the manufactures who make it don't think its effective. Once you start disagreeing with regulators and manufacturers and other independent scientists you are going down the route of conspiracy theories.

    The point of posting the article was to show anyone reading this thread the real world consequences of taking an unlicensed drug(when it comes to Covid treatment).



  • Registered Users Posts: 1,937 ✭✭✭PeadarCo


    It is absolute madness by the same rationale you could argue a person should start drinking bleach or something else crazy until its proven to be ineffective. Everything is toxic at a high enough dose.



  • Posts: 0 [Deleted User]


    The people who made it the patent has run out and they are making a new tablet type treatment you can take when positive for covid as are pfzier.

    Big pharma dont have any interest in repurposed drugs.

    There is no financial gain in it.

    Big shiny new products is best for profits.



  • Posts: 0 [Deleted User]


    Hospitalised because of covid or ivermectin?

    How many vaccinated people have been hospitalised and then died?

    By the way im vaccinated and think everyone should take the vaccine.



  • Registered Users Posts: 1,937 ✭✭✭PeadarCo


    It does. The best example to the Generics industry within Pharmaceuticals. For anyone unfamiliar with generics they a drugs that are whose patent has expired and don't attract the same high margins that patented drugs can be sold at. There are literally multi billion euro companies that specialise in generic manufacturing.

    Saying that companies aren't interested in repurposing drugs is also wrong. If you have the manufacturing and supply chain infrastructure set up for a particular drug, changing the dose or other small change required isn't a particularly big deal from a money or time perspective. Especially compared to developing a completely new drug. Even with the vaccines the biggest challenge for manufacturers has literally been the time it's taken to scale and develop production facilities and the supply chain in general to the required levels. If you have a existing drug, you already have a supplier of the active ingredient, manufacturing locations, personal etc already in place. If you are lauching a new drug in your company patented or generic all that needs to be developed from scratch and all the money and time that requires.

    With Invecterim it's not effective at treating Covid. If it was Pharmaceutical companies would be applying to get it approved by regulators. That's the harsh reality of it. Pushing Invecterim as any sort of Covid treatment is selling a scam based on current data. In Ireland at least one person has now ended up in hospital after listening to this conspiracy theory.



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  • Registered Users Posts: 16,708 ✭✭✭✭astrofool


    They do, they get 6 month exclusivity if it's approved for use for a new treatment, even without that, they're producing it already, for the cost of a properly run trial they have a factory already producing the medicine that they can ramp up (though I'd argue that a properly run trial would probably result in dropped sales given how many are buying it out of belief in the absence of approval).



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