Advertisement
If you have a new account but are having problems posting or verifying your account, please email us on hello@boards.ie for help. Thanks :)
Hello all! Please ensure that you are posting a new thread or question in the appropriate forum. The Feedback forum is overwhelmed with questions that are having to be moved elsewhere. If you need help to verify your account contact hello@boards.ie
Hi there,
There is an issue with role permissions that is being worked on at the moment.
If you are having trouble with access or permissions on regional forums please post here to get access: https://www.boards.ie/discussion/2058365403/you-do-not-have-permission-for-that#latest

The Ivermectin discussion

1212224262729

Comments

  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    Hardly. Lots of trials looked into ivermectin and repurposing other existing meds steroids such as dexamethasone, anti depressants, anti virals, anti malarials...

    We are seeing covid specific treatment meds being approved now.

    If you mean specifically meds to prevent infection rather than treatment vitamin D has popped up a lot. But like with other respiratory viruses maybe theres no 'shield' for the general population ... indications that if you are vitamin d deficient the vitamins could help.

    But there is also possibility people with low vitamin d have bad outcomes with covid not because of low vitamin d but because of the reasons they have low vitamin d.

    https://www.nature.com/articles/d42859-021-00052-9

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 85 ✭✭OTG


    "Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL " Vitamin D3 is dirt cheap to manufacture too and the process is out of patent. Been taking 5000iu per day during winter for years (now on 15000 to 25000 depending on sunlight exposure), my understanding was it is the essential building block of your immune systems Macrophage (hunter killer white blood cell).

    Boots on ground evidence can be seen by the lack of Covid deaths in the Homeless populations around the world.

    Vitamin C too if taken regularly can reduce the viral load build up via the process of electron donation thus destroying the virus cell wall by zapping it.



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    It's unproven and you could probably work up a study to say the same thing about a whole load of other ailments. Worldwide there are about 1bn people with Vitamin D deficiency anyway. There is a general Vitamin D is good for your immune system public health message and now a new programme to encourage parents to give their kids extra Vitamin D in winter.



  • Registered Users Posts: 2,292 ✭✭✭CruelSummer



    Posted this video on the main thread but it was reported and deleted as apparently no mention of Ivermectin allowed as it’s not approved as yet. I’ve never really paid attention to this drug as thought it would be similar to the other false dawns like remdesivir and others.

    However evidence presented in this video is compelling. Have we been sitting on a cheap, effective therapeutic for months? As Dr Campbell suggests that could have saved thousands of lives? Worse still is it appears from the data presented here that the Pfizer alternative isn’t as effective as Ivermectin…



  • Registered Users, Registered Users 2 Posts: 17,045 ✭✭✭✭astrofool


    There has been no data from any of the properly run Ivermectin trials that it's working as a prophylactic for SARS-COV2 or cure for COVID-19.

    There has been lots of circumstantial data from badly run trials that hasn't stood up to repetition.

    Pfizer drug and merck drug have passed trials and are in the approval phase or have been approved for emergency use.

    Ivermectin hasn't even gone for a review yet.



  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    The Pfizer treatment passed clinical trials.

    Ivermectin failed as a treatment in a 1500 patient trial run by McMaster University. And in other trials that studied it as an isolated treatment.

    Whatever it is it is not an effective treatment for covid. It would have been great if it had been but sometimes if it looks too good to be true it is.

    https://www.bbc.com/news/health-58170809

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 85 ✭✭OTG




  • Registered Users, Registered Users 2 Posts: 17,045 ✭✭✭✭astrofool


    It seems a good blog, I especially like the idea of the lizardman's constant (I hazard that on boards it's -gt 4%), but I assume you read the conclusion which was "great for worms, not for much else" as it seems to go against your other posts.

    • Ivermectin doesn’t reduce mortality in COVID a significant amount (let’s say d > 0.3) in the absence of comorbid parasites: 85-90% confidence
    • Parasitic worms are a significant confounder in some ivermectin studies, such that they made them get a positive result even when honest and methodologically sound: 50% confidence
    • Fraud and data processing errors are of similar magnitude to p-hacking and methodological problems in explaining bad studies (95% confidence interval for fraud: between >1% and 5% as important as methodological problems; 95% confidence interval for data processing errors: between 5% and 100% as important)
    • Probably “Trust Science” is not the right way to reach proponents of pseudoscientific medicine: ???% confidence


  • Registered Users Posts: 2,292 ✭✭✭CruelSummer


    Why are certain countries using it as a treatment such as India and Japan? Strange.



  • Registered Users Posts: 1,987 ✭✭✭PeadarCo


    Because they are not using Ivermectin to treat Covid.

    In India Ivermectin was given in conjunction with a number of other substances plus other other measures. Basically an example where paint was thrown at the wall in hope something sticks. There is no evidence that Ivermectin works when it comes to treating Covid. The Japan example has also been debunked in thread.

    To repeat the company that's makes Ivermectin doesn't think it works despite the massive financial incentive it has to produce the drug. It would be relatively simple to expand and retool production lines and supply chains. Far cheaper, quicker and less risky than attempting to develop a new drug.



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 17,045 ✭✭✭✭astrofool


    Which corner of the internet did you get that about Japan? That was an anti-vaxxer talking point a few weeks ago but has been debunked everywhere (do a quick search).

    India is the same (from the times of India):

    How ivermectin fails to work-Controversy behind the use of Ivermectin for COVID-19 (indiatimes.com)

    Amazingly, not having worms improves the health of those who had worms so they have better outcomes when they don't have worms.

    That post is a good indication of where you get your information from.



  • Posts: 0 [Deleted User]


    While it is true that it is an important element in the immune system... that fact alone should not motivate supplementation. There is no reason to think that adding more of it helps the immune system in any way.

    As an analogy - A builder might say "The most important thing for me to build this house is bricks". The response to that should be to say "Have you enough bricks to do the job right now then?" not to run off shouting "Get this guy as many bricks as possible!". More bricks will not help him. In fact getting more bricks might positively hinder him.

    Another analogy - If I told you how there is arsenic in your body and how and why it is important - would you suddenly feel compelled to add arsenic to your diet? I would hope not :)

    Most people - most of the time - have more than enough Vitamin D and supplementation does nothing for them. Vitamin supplementation can in fact be harmful and damaging. If you are pregnant or a doctor finds positive reason to recommend you supplement it then go for it. Other than that though - it's pretty pointless.

    It's even worse in the US than here in Ireland though. Over there there is no supplementation regulation. So there is no guarantee when buying a supplement of something like vitamin D that you are getting anywhere near (or even any at all in some cases.) of the vitamin you think you are. I genuinely do not know how this is regulated in Ireland actually. I would hope it is better than the US.

    Unfortunately such studies can not even agree what level even qualifies as "deficient". Let alone what levels of "deficiency" actually qualify as having any actual effect. It reminds me a lot of the studies (coincidently financed by bottled water companies, go figure) which suggested the majority of children were dehydrated all the time. To achieve this result they used measures when evaluating urine that no sane person, let alone any actual paediatrician, would use when qualifying a child as dehydrated.

    Germany is one of the countries where the doctors push Vitamin D supplementation on parents of young children. There seems to be very little evidence whatsoever that there is any point in them doing this.

    I think I already dealt with that video at some length in the thread already. Or one of his like it. And I already dealt with his video on the report about Vitamin D too. The guy makes awful videos and seems to know very little about what he is talking about. And I do not say that as a throw away comment. I evaluated his VitD video at quite a lot of length and the deficiencies in his abilities to evaluate the VitD report he was reading were numerous and massive.

    But by all means rather than me merely copy and pasting anything I wrote before - tell me which thing in the video - or which three things if you like - you found most "compelling" and I will go over them again.

    It depends what they are using it for? It is a great and wonderful drug! When it is used for the things it has been shown to be useful for that is. I am sure 100s of 1000s of people have used it to great effect.

    If you mean those countries are using it for covid however - that is indeed a good question. There is no reason for them to be doing it. Maybe they made a mistake. Maybe they were convinced by bad experts. Maybe it is just optics. Maybe they bent to the demands of the public who themselves where convinced of its efficacy (much like doctors bend to patients demands for anti biotics even when they have a virus and anti biotics would do nothing for them at all, and even harm them).

    It is more depressing than that though. A recent study did a review of all medications on the prescription lists in - I think it was the UK - and found a huge % of them (the majority if memory serves) have little or poor evidence for their efficacy. So the question there too is - why the hell are we using them?

    We should evaluate with extreme skepticism every drug. The fact some person or even some country is using that drug should never be taken as even a little evidence the drug is useful. Our own government had a truly awful report (which the guy in the video above praised of course) into Vitamin D making it sound like a wonder drug when in fact the evidence it is useful in most cases at all is at best scant and at worst truly awful.

    At the end of the day - governments are not medical people. It is simply not what they are qualified for/in most of the time. What they actually are qualified for most of the time is of course another interesting question :)



  • Registered Users Posts: 2,292 ✭✭✭CruelSummer


    Youre always trying to label fully vaccinated people as anti vaxx, and yet I still don’t know your own vaccination status.



  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    Should I pay attention to random anonymous posters on the internet or to a group of highly qualified professionals like those here?

    https://covid19criticalcare.com/

    ... and why?



  • Registered Users Posts: 59 ✭✭ligind


    Does ivm meta qualify as an anonymous poster on the internet ?

    Are you aware a paper based on the "highly qualified professionals" initial protocol was retracted recently ? , The second one they had retracted this year.



  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    If it is such an injurious and ineffective substance why have the WHO sponsored its use and praised the results, but yet kept the name of the substance out of their text?

    In another astonishing example of their incongruous and censorious policy, WHO has sponsored home covid treatment kits for the 240 million people living in the Indian province of Uttar Pradesh. The active treatment component in the kit is ivermectin and has been widely acknowledged to have been an important factor in virtually eradicating covid in that province. Yet despite heralding the success of this program on their official website, and listing all the other contents, they do not mention ivermectin at all, even though it is the only explanation of the massive drop in cases.

    https://bird-group.org/who-can-you-trust-on-ivermectin/



  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    I guess you mean the ivmmeta.com site, which I have previously linked to? No is my answer.

    The one that has this on its page ...


    I am heartened to know you have seen this and are in full agreement.



  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    Cos it is lies.

    Find us where the WHO authorised the contents of this kit.

    Also, what were the entire contents of the kit.

    In fact the WHO issued an advisory alert against the use of Ivermectin as a Covid treatment.


    Your posts should come with a health warning about fake news, they have such a distant relationship to the truth.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users Posts: 59 ✭✭ligind


    I am afraid we will have to agree to disagree . I dont understand how an anonymous site carries such credibility with some .

    The analysis shared by OTC earlier in the week should at the very least make people cautious about using that site as a source.



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    If, instead of spouting nonsense you had the interest in getting information you would not be unaware of this.

    Here is a link to the WHO page about this


    and just in case you have some difficulty in reading the pertinent part of the text I will even quote it for you

    WHO, which supported Uttar Pradesh government in training and micro planning for the activity, now has field officers on the ground to monitor and share real-time feedback with the government for immediate corrective action to ensure quality. On the inaugural day, WHO field officers monitored over 2,000 government teams and visited at least 10,000 households. WHO will also support the Uttar Pradesh government on the compilation of the final reports.

    Any further information on this you want get it yourself!



  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    Where is your source for the WHO approving the contents of the kit?

    What were the contents of the kit?

    And I don't mean the dark hole of the internet you get your fake news from.

    The Uttar Pradesh state government has initiated house-to-house active case finding of COVID-19 in rural areas to contain transmission by testing people with symptoms for rapid isolation, disease management and contact tracing.

    The kits were given to those who tested positive, but more importantly... all the contacts of those who test positive are quarantined and tested. But yeah, it must have been Ivermectin... how Ivermectin given to someone after they test positive is supposed to help prevent spread is not clear - bearing in mind all properly run trials have found no therapeutic benefit to Ivermectin.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 31,208 ✭✭✭✭Lumen


    There are references to Ivermectin being included in the kits on a couple of what look like mainstream news sites, but they also included vitamins, ORS and paracetamol so either they were throwing everything at the wall or using the opportunity to bundle up things which are generally useful to people underserved by medical services.

    Where's the thread on paracetamol curing Covid?




  • Registered Users, Registered Users 2 Posts: 17,045 ✭✭✭✭astrofool


    Japan hasn't approved Ivermectin, that line is following Japan's vaccine rollout which was lagging months behind Europe, he's just posted proof that vaccines work but is trying to put the credit on Ivermectin.

    He's a grifter and shill.



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 36,746 ✭✭✭✭BorneTobyWilde


    No one knows what to believe. What seems to be genuine people who are Doctors claiming it works, then some journalist writing an article about how it doesn't . Who do you believe.

    People who use ivermectin that was made for animals in doses that were made for animals are idiots, but the FDA Approved Human Version does stop the virus multiplying one in the body?



  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    Well don't believe anyone claiming Ivermectin is in use in Japan for starters, even if they are Doctors, unless they have some actual proof of that.

    Lots of the world's major health authorities have looked at Ivermectin, and don't see anything to justify it's approval.

    A 1500 patient trial run by McMaster university was stopped because Ivermectin (the human version) was having zero effect as a therapy.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    It seems some do not read.

    Kory highlighted the date that Ivermectin was recommended in Tokyo.

    The Japanese health officials have no idea what has caused the reduction in Covid there.

    Most say they are "puzzled". They also say it cannot be vaccination alone.

    Kory apparently hypothesises that IVM is involved. For me that is not shown anywhere, but his hypothesis is as valid as most until it is shown to be unfounded and a better explanation of the "puzzle" that is Japan appears.



  • Posts: 5,869 [Deleted User]


    And herein lies the duality of your anti-vax pseudo scientist.

    "I can't believe that you won't believe these cherry-picked doctors and medical professionals. Never mind that they seem to be being misquoted and their results are being misrepresented to say something they aren't, everyone should believe them because they're doctors"

    "Cool.....what about the medical professionals who advocate taking the vaccine"

    "fcuk them lads, bought and paid for the lot of 'em, sure you couldn't trust a single one of them"



  • Posts: 5,869 [Deleted User]


    https://apnews.com/article/business-science-health-coronavirus-pandemic-c2b50063ac65943686a4995a6cf230c3


    This week, the top U.S. professional groups for doctors and pharmacists appealed for an “immediate end” to the drug’s use outside of research. “We are urging physicians, pharmacists, and other prescribers — trusted healthcare professionals in their communities — to warn patients against the use of ivermectin outside of FDA-approved indications and guidance,” said the American Medical Association and two pharmacist groups.

    What about these medical professionals? Like, why are you going out of your way to find any evidence, no matter how ropey, to use to dismiss people who's entire career is built on studying and advising on this kind of thing?

    By mid-August U.S. pharmacies were filling 88,000 weekly prescriptions for the medication, a 24-fold increase from pre-COVID levels, according to the Centers for Disease Control and Prevention. Meanwhile, U.S. poison control centers have seen a five-fold increase in emergency calls related to the drug, with some incidents requiring hospitalization

    More irony staring everyone in the face. How did we ever get to the stage where people are mistrusting of 'experimental' vaccines yet are happy enough to bang a load of livestock medicine into their system while calling everyone else sheep.



  • Advertisement
  • Registered Users Posts: 59 ✭✭ligind


    The flccc doctors for example have had 2 of their papers retracted this year , they also touted some studies that now it seems may never have actually happened.

    The Japan tweet by Kory earlier in the thread is fairly bizarre.

    Some of the "journalists" are people who analysed the ivm studies and found significant issues that lead to a number of retractions.

    There is no evidence that ivm stops the virus multiplying in the body ,there was laboratory work that showed it did have an impact but required ivm levels that would not be possible in humans.



  • Posts: 18,962 ✭✭✭✭ [Deleted User]


    That Kory doctor is an Ivermectin Shill and at this stage at best dubious

    He had a paper retracted recently (November 2021) as a hospital which had data cited in the paper corrected the mortality data which was completely incorrect in a manner to make his/FLCCC MATH+ protocol (that includes Ivermectin and which he had testified to Senate about) to appear effective.

    Furthermore, less than half of the patients were on the protocol and of those who were, the mortality rate was actually high!

    Like that is major data manipulation. The MATH don't add up!

    ‘We have conducted a careful review of our data for patients with COVID-19 from March 22, 2020 to July 20, 2020, which shows that among the 191 patients referenced in Table 2 that the mortality rate was 10.5%, rather than 6.1%.


    In addition, of those 191 patients, only 73 patients (38.2%) received at least 1 of the 4 MATH+ therapies, and their mortality rate was 24.7%. Only 25 of 191 patients (13.1%) received all 4 MATH+ therapies, and their mortality rate was 28%.’


    https://retractionwatch.com/2021/11/09/bad-math-covid-treatment-paper-by-pierre-kory-retracted-for-flawed-results/



  • Registered Users, Registered Users 2 Posts: 33,670 ✭✭✭✭odyssey06


    The puzzle is why anyone would believe this fake news.

    It wasn't even recommended. That was one doctor on a solo run who was chair of a non statutory medical organisation. It was never recommended by any official medical authority or body.

    Ivermectin is not listed as an approved treatment for the virus by Japan's Pharmaceuticals and Medical Devices Agency, a government organization in charge of reviewing drugs and medical devices. Inaccurate claims that Japan authorized ivermectin for COVID-19 began circulating online after Haruo Ozaki, chairman of the Tokyo Medical Association, recommended the drug for COVID-19 patients during a press conference on Aug. 13. The medical group and Ozaki are not affiliated with the Japanese government, and members of the organization can only provide suggestions

    https://eu.usatoday.com/story/news/factcheck/2021/11/05/fact-check-japan-has-not-halted-vaccines-ivermectin/6232580001/

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Posts: 18,962 ✭✭✭✭ [Deleted User]


    Here's an interesting article on Kory and Marik and the FLCCC that's worth 10 minutes reading whatever side of the discussion you are on

    Covid 19 is not their first rodeo - they have a pre-covid background in giving people false hope in other areas of medicine (Sepsis)

    Aside from the fact that they had some initial success (with others) with steroids that does reduce death in some serious cases (needs to be carefully prescribed), which they leveraged off, since then they have been worthy of scepticism




  • Posts: 0 [Deleted User]


    That is why you should not believe people. You should believe the studies their positions are based on. It does not matter if they are a "journalist" a "doctor" or a "homeless vagrant". Who is saying things is not as important as the evidence upon which they are saying it.

    So do not confuse yourself with worrying about what their background is - worry about the hard and actual data they are citing (if any) when pushing their opinion.

    There is for example a study showing that Ivermectin inhibits the viruses ability to replicate. But in a petri dish. "In vitro" results as they are called do not translate into real world biological bodies all that often. The best a positive

    Worse the dosage required to even get that result in a petri dish is many 100s of times larger than any human dose or even animal dose.

    So no there is no data - from journalists or doctors - that I am aware of that suggests it has any positive effect on Covid in the body or that it has any benefit whatsoever in A) Treating or B) Preventing such an infection.

    So what you get instead is people - usually but not always people who are entirely lay people when it comes to this kind of science - pointing at how Ivermectin distribution was correlated with positive effects on Covid Numbers or Hospital numbers. Usually while 100% ignoring all the other things that correlated at the same time.

    The example of this I have seen most is when "medicine packs" were distributed in one country with quite a few things - including masks as it happens - inside it. While at the same time an agressive program of testing and isolation and education was performed. And during all of this Covid numbers dramatically dropped in that country. So the Ivermectin fetishists noted that yes indeed it was one of the things in that medicine pack - ignored everything else that was done at the same time and everything else that was in the pack etc etc etc - and declared this to be evidence that Ivermectin works.

    It would be like me giving all of Ireland a pack with 20 different drugs - engaging in a lot of testing in all IRish counties at the same time - strictly isolating anyone who tests positive - educating everyone else on hygiene and distancing rules rigorously - dropping a hammer on everyones foot - and coming out at the end and saying "The COVID numbers just dropped massively - dropping hammers on peoples feet must cure it - look how the numbers went down when we did it!!!".

    That really is the intellectual level we have to deal with on some of the people pushing this drug at the moment.

    Does not mean of course that tomorrow or next month or next year some data might come out showing the drug works. Keep an open mind and all! There just is none so far. Like really. None at all.



  • Registered Users, Registered Users 2 Posts: 17,045 ✭✭✭✭astrofool


    Care to respond? What health officials are puzzled? The drop is pretty much matching other countries during the vaccine rollout so they're pretty bad health officials if they can't figure out the link.

    Especially as IVM isn't being used in any widespread way in Japan.



  • Registered Users, Registered Users 2 Posts: 7,190 ✭✭✭circadian


    I can't tell if you're saying I'm an anti-vax pseudo scientist?



  • Registered Users Posts: 857 ✭✭✭PintOfView


    Here is a link to the WHO page about this

    Nowhere on that page does it mention Ivermectin!

    and just in case you have some difficulty in reading the pertinent part of the text I will even quote it for you

    "WHO, which supported Uttar Pradesh government in training and micro planning for the activity, now has field officers on the ground to monitor and share real-time feedback with the government for immediate corrective action to ensure quality. On the inaugural day, WHO field officers monitored over 2,000 government teams and visited at least 10,000 households. WHO will also support the Uttar Pradesh government on the compilation of the final reports."

    Any further information on this you want get it yourself!

    Do you mean that I have to search around to see if Ivermectin was at all connected with this initiative? Why can't you just provide a link that shows why you think this?

    At the bottom of that same page you linked to here is what they said:

    "Those with symptoms are tested and given medicine kits and information on quarantining and isolation, both at home and in hospitals. People without signs of COVID-19 are urged to get vaccinated and follow COVID-appropriate behaviours to prevent transmission in rural areas of India’s most populated state."

    So why are they only saying that people should get vaccinated? No mention of Ivermectin!



  • Registered Users, Registered Users 2 Posts: 31,208 ✭✭✭✭Lumen


    @PureIsle wrote

    The Japanese health officials have no idea what has caused the reduction in Covid there.

    Most say they are "puzzled". They also say it cannot be vaccination alone.

    Article is behind registration wall but worth a read.

    https://www.japantimes.co.jp/news/2021/11/18/national/delta-variant-self-destruction-theory/

    Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven by the supercontagious delta variant, suddenly come to an abrupt end following a seemingly relentless rise in new infections? And what made Japan different from other developed countries that are now seeing a fresh surge in new cases?

    According to one group of researchers, the surprising answer may be that the delta variant took care of itself in an act of “self-extinction.

    Three months after the delta variant spurred record daily nationwide caseloads of nearly 26,000, new COVID-19 infections in Japan have plummeted, dropping below 200 in recent weeks. Highlighting that drop was the fact that no deaths were reported on Nov. 7 — the first time that had happened in about 15 months

    Many scholars point to a variety of possibilities, which include one of the highest vaccination rates among advanced countries with 75.7% of residents fully vaccinated as of Wednesday. Other potential factors are the social distancing and mask-wearing measures that are now deeply embedded in Japanese society.

    But the chief reason may be related to the genetic changes that the coronavirus undergoes during reproduction, at a pace of around two mutations per month. According to a potentially revolutionary theory proposed by Ituro Inoue, a professor at the National Institute of Genetics, the delta variant in Japan accumulated too many mutations to the virus’s error-correcting, non-structural protein called nsp14. As a result, the virus struggled to repair the errors in time, ultimately leading to “self-destruction.”

    Studies have shown that more people in Asia have a defense enzyme called APOBEC3A that attacks RNA viruses, including the SARS-CoV-2 virus that causes COVID-19, when compared to people in Europe and Africa.




  • Posts: 0 [Deleted User]


    ^ To add to that article above - one thing that has been bothering me about vaccination rates in countries - and anti vax people or pro Ivermectin people citing them - is that I have seen very little talk about relative rates and what they mean. In fact I confess my own relative ignorance on this too in that I would prefer people better informed go into it deeper than I would.

    What I mean is, let us say you have three countries and their vaccination rates are 69% 72% and 75%. And people are thinking "We are so confused why Japan has such great numbers. It can not be the vaccine alone - sure they are only 3% ahead of one competing country and 6% ahead the next!"

    Are such people assuming a linear scale here? Is such an assumption warranted? Should the effect we observe between country A and B - be the same as that between B and C?

    Or is it possible that the effects are non-linear and at certain thresholds (such as reaching the threshold for herd immunity in some vaccines) the effect measured is much greater from one 3% jump than another?

    One point of vaccination of any disease in general is to close off transmission vectors in a society. That is part of what herd immunity means for example. I would suspect that even a seemingly small % advantage one country has over another in terms of uptake - can have a non linear larger observable end effect on the virus than the average person suspects.

    Strangely I do not see the more vocal people mention this however. Including retired nurse John Campbell (though admittedly I have only digested about 10% of his released materials so apologies if he actually has!).



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle


    In the case of Japan, and their sudden drop in infections and deaths, I fail to see how Ivermectin could be in any way causal.

    IVM was not universally used, so even if it could stop the virus dead in its tracks, to have that happen within 2 weeks of a statement purporting to allow people to use it is not believable.

    If it were a roll out similar to Uttar Pradesh then I could see a very strong correlation but not in the case of Japan.

    There is a theory that the virus just mutated itself out of existence, in a somewhat similar manner to what is theorised about Covid-1.

    That appears to be as valid a theory as any other.

    Post edited by PureIsle on


  • Posts: 0 [Deleted User]


    ^ Further a statement "allowing people to use it" is irrelevant while evaluating the statistics on the matter. A statement is not medicine. To have any relevance at all one would have to measure actual implementation of such a statement (if any). How was it being used before the statement. How was it being used after. What was the actual transition time between the two in increments? Was uptake instant? Linear? Scalar? What is the period of effect meant to be? What is even the effect meant to be, treatment or prevention? And much more.

    Those simply saying "Here is a graph of infections and a statement was made by one guy on this date" are literally saying nothing at all but using as many words as possible in which to say it.



  • Registered Users Posts: 857 ✭✭✭PintOfView


    Agreed. And if Ivermectin was involved in the sudden reduction in Covid in Japan, then it would surely have involved large quantities of the drug being distributed and administered to a significant percentage of the population, and in a short timescale. To achieve this large quantities of the drug would need to be manufactured, procured, and distributed, and there would surely be evidence of this, and it should be easy to verify. This whole claim about Japan is completely implausible, and doesn't hold any water, imo.



  • Registered Users Posts: 336 ✭✭NaFirinne


    Dr. John Campbell covers the Japanese usage of ivermectin quite well.

    While it's not offically used the Japananese Governemnt did allow their people to determine themselves if the want to use it or not.

    But it's not conclusive that it caused the reduction. I wonder if there has been large side effects to actually using this in Japan. As from what I gather if the human form of Ivermectin is taken in the recommended dosages that the side effects are not harmfull.


    I wish more goverments would allow there doctors to be allowed to prescribe it.





  • Registered Users Posts: 336 ✭✭NaFirinne


    The current vaccines unfortuntely don't stop the spread of infection. we can see that the most vaccinated countries are experiencing sharp rises in cases over the winter months.

    However it does look like they are reducing the number of deaths greatly. However we do need to keep up the booster shots regularly to keep that up as the current vaccines appear to waine over a short period of time.

    We might need something that works as treatment as no one still knows what the long term effects of having all these new types of vaccines so regularly will have.



  • Registered Users Posts: 1,987 ✭✭✭PeadarCo


    The problem is Ivermectin is proven not to work. Any credible study shows it doesn't work. The company that makes it doesn't think it works. There is plenty of research being done on treatments that actually work and have actual evidence that they work. Many of these treatments are actually used on top of that.

    The reason I think Ivermectin has been adopted as the drug of day for conspiracy theorists is that its a more respectable way to say the pandemic(or at least the severity) is a hoax/plot. If only we used X drug in this case Ivermectin the whole pandemic would go away. You can't do the same with paracetamol or any other medication in widespread use.



  • Posts: 0 [Deleted User]


    ^ Actually I genuinely have forgotten why the - shall we call them alternative medicine types - focused on Ivermectin and then the discussion got so polarised. Is it partly traceable back to Trump maybe? Did he tout it and it went down hill from there and became a Pro-Anti Trump thing?

    I genuinely can't remember any more :)



  • Posts: 0 [Deleted User]



    John the retired nurse does not "cover" anything very well at all. He reads things very well - in a very pleasant to listen to voice - but he really does not "Cover" anything well at all. I took apart his video on Vitamin D for example and the plethroa of ways he showed he has no idea how to read a report - let alone an actual scientific study.

    And that is not a fault against him - reading studies of that nature is not part of the training he would have had to do the work he did. Expecting him to know how to dissect a study is like expecting a car mechanic to know the physics rules of combustion. It's just not required for his job even if he - just like the mechanic - work with the results of that science every day!

    But a lot of people who see the word "Dr." in front of a name of someone like him do not realise that. It's amazing - for example - just how little neurosurgeons have to know about neurology.

    That little rant over though - even I have to admit that his Japan video was not his worst. Except for him starting it off with that nudge nudge "I guess it's all a coincidence" lark - he did better than his usual fare here. But again - he did not cover it so much as just read it out. I do like his voice I have to say. I could listen to him read the phone book.



  • Registered Users Posts: 7,237 ✭✭✭mcmoustache


    I don't think it was Trump touting this one. It was just the usual cranks and quacks (or alternative medicine types as you kindly described them). I think that what polarised the discussion was that one group was believing the quacks and the other was believing the consensus among the medical community and those two sides didn't agree with each other.

    From my own point of view, I think it would be great if it could be shown to work. The more tools we have to fight covid, the better. On the other hand, I'm a bit confused about the end-game here. What it ivermectin turns out to be a miracle cure for covid? Are we expecting the global population to take a pill every day when we already have vaccines that can be taken once every six months?



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 172 ✭✭PureIsle



    Trump voiced his opinion on Hydroxychloroquin.

    The 'quacks' as you term them are as, and a lot of times better, qualified than any of the 'consensus among the medical community' persons you chose to believe.

    That is what is really wrong with your denigrating the alternative view as "quackery" in the modern sense.

    I suppose you do know that medical doctors were the ones known as quacks before they were organised into what they have now become.

    If you truly want to know whether IVM works or not the you should be supporting those who are calling for 'official' studies and not deliberately doing your best to dismiss its possible use as a treatment by referring dismissively to those who hold that view.

    That belies your claim that "it would be great if it could be shown to work".



Advertisement